Luthfiyyah Mutsnaini

Eduardo de la Vega

Fernanda Macarena Navarro

Junfang Song

Shannon Payne Bourke

Lukasz Sitko

Banyoon Cheon

Arno Alpi

Alper Akay

Ana Agostinho

Ashley Craig

Aymeric Bailly

Alexander Holmes

Bettina Meier

Bin Wang

Björn Schumacher

Ehsan Pourkarimi

Federico Pelisch

Giulio Maffioletti

Neda Masoudi

Pablo Ibáñez Cruceyra

Rachael Rutkowski

Remi Sonneville

Sandra Moser

Sarah-Lena Offenburger

Sebastian Greiss

Simon Bertonlini

Virkram Narayam

M. Yasir Malik

Ye Hong

Victor Gonzlez-Huici

The Gartner Lab, now located at the Institute for Basic Science (IBS) Center for Genomic Integrity (CGI) at the Ulsan National Institute of Science and Technology (UNIST), focuses on elucidating the basic mechanisms of mutagenesis and fail-safe mechanisms of genome maintenance. It uses C. elegans as a model to study DNA damage-dependent apoptosis induction in the germ line, employing advanced genetics, genomics, cell biology, and next-generation sequencing. The lab also utilizes mammalian cells with normal karyotypes for genome engineering. Research aims to understand fundamental mechanisms of cancer development and improve cancer therapy agents. The lab is involved in national and international collaborations.

Gartner Lab은 울산과학기술원(UNIST) 기초과학연구원(IBS) 유전체 보전 연구단(CGI)에 위치하며, 돌연변이 유발의 기본 메커니즘과 게놈 유지의 안전 장치 메커니즘을 연구한다.  C. elegans를 모델로 사용하여 생식 세포에서 DNA 손상 의존적 세포 사멸 유도를 연구하며, 첨단 유전학, 유전체학, 세포 생물학 및 차세대 염기서열 분석법을 활용한다. 또한 정상 핵형을 가진 포유류 세포를 사용하여 게놈 엔지니어링을 수행한다. 암 발생의 기본 메커니즘을 이해하고 암 치료제 개선을 목표로 하며, 국내외 연구 협력에 참여하고 있다.

Tardigrades: Trained to be hardy in the face of DNA damage

Comprehensive whole genome sequencing reveals origins of mutational signatures associated with aging and temozolomide chemotherapy

SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegant

COSA-1 mediated pro-crossover complex formation promotes meiotic crossing over in C. elegans

The histone chaperone SPT2 regulates chromatin structure and function in Metazoa

Short-range end resection requires ATAD5-mediated PCNA unloading for faithful homologous recombination

Caenorhabditis elegans NSE3 homolog (MAGE-1) is involved in genome stability and acts in inter-sister recombination during meiosis

Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells

Experimental systems for the analysis of mutational signatures: no 'one-size-fits-all' solution

DNA repair, recombination, and damage signaling

Bub1 kinase in the regulation of mitosis

Protection of the C. elegans germ cell genome depends on diverse DNA repair pathways during normal proliferation

The Last Chance Saloon

C. elegans genome-wide analysis reveals DNA repair pathways that act cooperatively to preserve genome integrity upon ionizing radiation

Mutational signatures are jointly shaped by DNA damage and repair

Human ANKLE1 is a nuclease specific for branched DNA

Analysis of mutational signatures in C. elegans: Implications for cancer genome analysis

Ewing sarcoma protein promotes dissociation of poly (ADP‐ribose) polymerase 1 from chromatin

The balance between mono-and NEDD8-chains controlled by NEDP1 upon DNA damage is a regulatory module of the HSP70 ATPase activity

Germline survival and apoptosis

6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33

Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment

The conserved LEM-3/Ankle1 nuclease is involved in the combinatorial regulation of meiotic recombination repair and chromosome segregation in Caenorhabditis elegans

Biochemical and structural properties of fungal holliday Junction-Resolving enzymes

Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers

6-hydroxydopamine (6-OHDA) oxidative stress assay for observing dopaminergic neuron loss in Caenorhabditis elegans

LEM-3 is a midbody-tethered DNA nuclease that resolves chromatin bridges during late mitosis

Comparative genetic, proteomic and phosphoproteomic analysis of C. elegans embryos with a focus on ham-1/STOX and pig-1/MELK in dopaminergic neuron development

Multi-omics analyses of starvation responses reveal a central role for lipoprotein metabolism in acute starvation survival in C. elegans

A role for the nonsense-mediated mRNA decay pathway in maintaining genome stability in Caenorhabditis elegans

CUL-2 LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis

Caenorhabditis elegans BUB-3 and SAN-1/MAD3 spindle assembly checkpoint components are required for genome stability in response to treatment with ionizing radiation

A SUMO-dependent protein network regulates chromosome congression during oocyte meiosis

Deep proteome analysis identifies age-related processes in C. elegans

Micro‐proteomics with iterative data analysis: proteome analysis in C. elegans at the single worm level

The SMC-5/6 complex and the HIM-6 (BLM) helicase synergistically promote meiotic recombination intermediate processing and chromosome maturation during Caenorhabditis elegans meiosis

E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

Both chromosome decondensation and condensation are dependent on DNA replication in C. elegans embryos

Crystal Structure of a Eukaryotic GEN1 Resolving Enzyme Bound to DNA

Global Proteomics Analysis of the Response to Starvation in C. elegans

Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers

Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

Having a direct look: analysis of DNA damage and repair mechanisms by next-generation sequencing

Tetraspanin (TSP-17) protects dopaminergic neurons against 6-OHDA-induced neurodegeneration in C. elegans

GEN1 from a thermophilic fungus is functionally closely similar to non-eukaryotic junction-resolving enzymes

C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency

Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases

Germ cell apoptosis and DNA damage responses

The NM23-H1/H2 homolog NDK-1 is required for full activation of Ras signaling in C. elegans

Stress response: anything that doesn’t kill you makes you stronger

If you don't want them shed them

RNA-binding protein GLD-1/quaking genetically interacts with the mir-35 and the let-7 miRNA pathways in Caenorhabditis elegans

LAAT-1 is the lysosomal lysine/arginine transporter that maintains amino acid homeostasis

The dynamics of replication licensing in live Caenorhabditis elegans embryos

Evidence that CED-9/Bcl2 and CED-4/Apaf-1 localization is not consistent with the current model for C. elegans apoptosis induction

Methods for studying the DNA damage response in the Caenorhabditis elegans germline

The shark in us: learning about the evolution of the p53 regulatory circuit

Stable-isotope labeling with amino acids in nematodes

CDC-48/p97 coordinates CDT-1 degradation with GINS chromatin dissociation to ensure faithful DNA replication

Regulation of Caenorhabditis elegans p53/CEP-1–Dependent Germ Cell Apoptosis by Ras/MAPK Signaling

Caenorhabditis elegans radiation responses

Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2

The Caenorhabditis elegans homolog of Gen1/Yen1 resolvases links DNA damage signaling to DNA double-strand break repair

Phylogeny and function of the invertebrate p53 superfamily

The Caenorhabditis elegans Werner syndrome protein functions upstream of ATR and ATM in response to DNA replication inhibition and double-strand DNA breaks

Cell-nonautonomous regulation of C. elegans germ cell death by kri-1

Tagging the dead: a bridging factor for Caenorhabditis elegans phagocyte receptors

Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation

The NM23 family in development

Functional dissection of Caenorhabditis elegans CLK-2/TEL2 cell cycle defects during embryogenesis and germline development

The MRT‐1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans

C. elegans SIR-2.1 translocation is linked to a proapoptotic pathway parallel to cep-1/p53 during DNA damage-induced apoptosis

Cell cycle progression requires the CDC-48UFD− 1/NPL− 4 complex for efficient DNA replication

Transcriptional profiling in C. elegans suggests DNA damage dependent apoptosis as an ancient function of the p53 family

The Caenorhabditis elegans AMP-activated protein kinase AAK-2 is phosphorylated by LKB1 and is required for resistance to oxidative stress and for normal motility and foraging behavior

Caenorhabditis elegans prom-1 is required for meiotic prophase progression and homologous chromosome pairing

A conserved checkpoint pathway mediates DNA damage–induced apoptosis and cell cycle arrest in C. elegans

FAR1 links the signal transduction pathway to the cell cycle machinery in yeast

Excess Mcm2–7 license dormant origins of replication that can be used under conditions of replicative stress

The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis

Signal transduction in Saccharomyces cerevisiae requires tyrosine and threonine phosphorylation of FUS3 and KSS1.

Combined functional genomic maps of the C. elegans DNA damage response

Caenorhabditis elegans HUS-1 is a DNA damage checkpoint protein required for genome stability and EGL-1-mediated apoptosis

MSG5, a novel protein phosphatase promotes adaptation to pheromone response in S. cerevisiae.

Genetic and cytological characterization of the recombination protein RAD-51 in Caenorhabditis elegans

Translational repression of C. elegans p53 by GLD-1 regulates DNA damage-induced apoptosis

MAP kinase-related FUS3 from S. cerevisiae is activated by STE7 in vitro

C. elegans ced-13 can promote apoptosis and is induced in response to DNA damage.

Anton Gartner Lab

교수님 소개

안톤 가트너

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Tardigrades: Trained to be hardy in the face of DNA damage

Comprehensive whole genome sequencing reveals origins of mutational signatures associated with aging and temozolomide chemotherapy

SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegant

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

안톤 가트너

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Tardigrades: Trained to be hardy in the face of DNA damage

Comprehensive whole genome sequencing reveals origins of mutational signatures associated with aging and temozolomide chemotherapy

SMC-5/6 complex subunit NSE-1 plays a crucial role in meiosis and DNA repair in Caenorhabditis elegant

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집