Thet Thet Swe

Gunhyu BAE

Ramar THANGAM

The Dynamic Nano Systems Lab develops magnetically controllable nanomaterials using magnetic nanomaterials with tunable chemistry through the dynamic application of an external magnetic field. The lab also engineers light-responsive dynamic systems using photonic nanomaterials for biomedical applications, such as remotely controlled cell modulation and molecule delivery. Research includes exploiting self-assemblies induced by various stimuli to demonstrate self-assembly capable of dynamically changing morphology via magnetic fields and light. Furthermore, the lab utilizes ultrasound as a stimulus to control dynamic processes in nanostructured materials involving chemical, mechanical, magnetic, photonic, electrical, and thermal energy transformations.

Dynamic Nano Systems Lab은 외부 자기장의 동적 적용을 통해 화학적 조절이 가능한 자기 나노 물질을 사용하여 자기적으로 제어 가능한 나노 물질을 개발한다. 광자 나노 물질을 활용하여 원격 제어 세포 조절 및 분자 전달과 같은 생물 의학 응용 분야를 가능하게 하는 광 반응성 동적 시스템을 개발한다. 다양한 자극에 의해 유도된 자기 조립을 활용하여 자기장 및 빛을 통해 형태를 동적으로 변화시킬 수 있는 자기 조립을 시연한다. 화학적, 기계적, 자기적, 광자, 전기적 및 열에너지 변환을 포함하는 나노 구조 재료의 동적 프로세스를 제어하기 위해 초음파를 자극으로 활용한다.

Reversible chemistry for cancer therapy and diagnosis

Covalent Organic Frameworks for Ferroptosis Cancer Therapy

Site-specific transformable nanostructures for cancer therapy and diagnosis

Polymer/zeolitic imidazolate framework-8 nanosystems for photothermal therapy

Biomimetic Dynamics of Nanoscale Groove and Ridge Topography for Stem Cell Regulation

Thermoelectric and pyroelectric cancer therapy

Engineered intrinsically conducting polymer/MXene smart platforms: Fabrication, clinical translatability, and biomedical applications

Chemical Design of Magnetic Nanomaterials for Imaging and Ferroptosis-Based Cancer Therapy

Serial stimuli-responsive theranostic nanomaterials for cancer therapy and imaging

Ligand Inter-Relation Analysis Via Graph Theory Predicts Macrophage Response

Smart Nanomaterials for Multimodal Theranostics and Tissue Regeneration

Sustainable cancer therapy

Antimicrobial carbon materials-based quantum dots: From synthesis strategies to antibacterial properties for diagnostic and therapeutic applications in wound healing

Dynamic hierarchical ligand anisotropy for competing macrophage regulation in vivo

Peptide-harnessed supramolecular and hybrid nanomaterials for stimuli-responsive theranostics

Magnetic Control of Multiscale Ligand Nanoarchitecture Regulates Stem Cell Fate

Stimuli-responsive smart nanomaterials for theranostics of urological cancers

Nanodiamond-Based Sensing: A Revolution for Biosensors in Capturing Elusive Bio-signals in Living Cells

Multimodal synergistic ferroptosis cancer therapy

Engineered Extracellular Vesicles for Combinatorial Cancer Therapy and Imaging

Biomolecule-Based Engineered Nanoparticles for Cancer Theranostics

Mechanobiological Dynamics-Inspired Mechanomodulatory Biomaterials

Tuning Liganded Nanocrack Geometry for Dynamic Regulation of Host Macrophages

Biomimetic Carbon-based Nanomaterials: From Design Strategies to Next-Generation Biosensing and Theranostic Applications

Graphene oxide-engineered chitosan nanoparticles: Synthesis, properties, and antibacterial activity for tissue engineering and regenerative medicine

Stimuli-responsive nanomaterials for wireless and precise neuromodulation

Cell fate regulation by hyperthermia: cancer, stem cells, and immune system

Integrating microfluidic and bioprinting technologies: advanced strategies for tissue vascularization

Antimicrobial PLGA-based micro/nanoparticles for nanomedicine of pulmonary diseases: From respiratory infections to pulmonary hypertension and fibrosis

Dual-Targeted Molecular MRI Nanoprobe for Precision Cardiovascular Imaging

Mesenchymal Stem Cell-Inspired Microneedle Platform for NIR-responsive Immunomodulation and Accelerated Chronic Wound Healing

Responsive probes for in vivo magnetic resonance imaging of nitric oxide

A Body Conformal Ultrasound Receiver for Efficient and Stable Wireless Power Transfer in Deep Percutaneous Charging

Form Factor-free Magneto-Triboelectric Generator for Standalone Power Line IoT Applications

Print-and-Roll Hierarchically Structured Piezoelectric Scaffolds for Exercise-Driven Cartilage Regeneration

Nanoporous structures-based biosensors for environmental and biomedical diagnostics: Advancements, opportunities, and challenges

Joule-Assisted Nanotherapeutic Urethral Stent (JANUS) for Spatiotemporal Theragenerative Treatment of Urethral Strictures

Low-voltage Driven Ferroelectric Thermal Switch

Gelatin-integrated carbon nanomaterials in nanomedicine: From biosensing and bioprinting to tissue engineering and other biomedical applications

Photon-driven dye induction pyroptosis: An emerging anti-tumor immunotherapy paradigm

Pyroptosis-Inducing Nanoplatform with Plasmonic-Enhanced Phototherapy for Metastasis-Suppressive Cancer Immunotherapy

Development of Cultivated Fish Meat: Advances in Cellular Agriculture, Biomaterials, and Scaffolding Techniques

A One Stone Three Birds Paradigm of Photon-driven Pyroptosis Dye for Amplifying Tumor Immunotherapy

Highly wrinkled reduced graphene oxide nanocomposite coating for a multiplexed electrochemical biosensor

Recent developments of small-molecule fluorescent probes for the detection of hydroxyl radical in biological systems

Apigenin-loaded nanoparticles for obesity intervention through immunomodulation and adipocyte browning

Immunoengineering strategies using nanoparticles for obesity treatment

UV-activated Seed Strategy for PromotingTextured Colossal Grain Growth in Templated Ceramic Processing

High-power Piezoelectric Ceramics with Superior Figure-of-Merits through Tailored Grain Engineering

Simultaneously achieving large transducer Figure-of-merits and high Curie temperature through acceptor dopingin PMN-PAN-PZT ternary system for high power applications

Calcium phosphate-bearing matrices induce osteogenic differentiation of stem cells through adenosine signaling

Liquid-crystalline semiconducting copolymers with intramolecular donor− acceptor building blocks for high-stability polymer transistors

Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells

In situ self-assembly for cancer therapy and imaging

Stimuli-responsive ferroptosis for cancer therapy

Flexible patch with printable and antibacterial conductive hydrogel electrodes for accelerated wound healing

Carbon-coated three-dimensional MXene/iron selenide ball with core–shell structure for high-performance potassium-ion batteries

Static and dynamic: evolving biomaterial mechanical properties to control cellular mechanotransduction

Cancer therapeutics based on diverse energy sources

Mineralized gelatin methacrylate-based matrices induce osteogenic differentiation of human induced pluripotent stem cells

Enhanced Optical Properties and Stability of CsPbBr3 Nanocrystals through Nickel Doping

One-dimensional nanomaterials for cancer therapy and diagnosis

Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering

Immunoregulation of macrophages by dynamic ligand presentation via ligand–cation coordination

Mechanical stimuli-driven cancer therapeutics

Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Personalized Electronic Tattoo for Healthcare Realized by On‐the‐spot Assembly of Intrinsically Conductive and Durable Liquid‐metal‐composite

Near-infrared light-controlled regulation of intracellular calcium to modulate macrophage polarization

Harnessing the therapeutic potential of extracellular vesicles for biomedical applications using multifunctional magnetic nanomaterials

Heemin Kang

Synthetic matrices emulating the physicochemical properties of tissue-specific ECMs are being developed at a rapid pace to regulate stem cell fate. Biomaterials containing calcium phosphate (CaP) moieties have been shown to support osteogenic differentiation of stem and progenitor cells and bone tissue formation. By using a mineralized synthetic matrix mimicking a CaP-rich bone microenvironment, we examine a molecular mechanism through which CaP minerals induce osteogenesis of human mesenchymal stem cells with an emphasis on phosphate metabolism. Our studies show that extracellular phosphate uptake through solute carrier family 20 (phosphate transporter), member 1 (SLC20a1) supports osteogenic differentiation of human mesenchymal stem cells via adenosine, an ATP metabolite, which acts as an autocrine/paracrine signaling molecule through A2b adenosine receptor. Perturbation of …

The ability to control the molecular organization of electronically active liquid-crystalline polymer semiconductors on surfaces provides opportunities to develop easy-to-process yet highly ordered supramolecular systems and, in particular, to optimize their electrical and environmental reliability in applications in the field of large-area printed electronics and photovoltaics. Understanding the relationship between liquid-crystalline nanostructure and electrical stability on appropriate molecular surfaces is the key to enhancing the performance of organic field-effect transistors (OFETs) to a degree comparable to that of amorphous silicon (a-Si). Here, we report a novel donor−acceptor type liquid-crystalline semiconducting copolymer, poly(didodecylquaterthiophene- alt -didodecylbithiazole), which contains both electron-donating quaterthiophene and electron-accepting 5,5′-bithiazole units. This copolymer exhibits …

Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as a promising approach to cancer immunotherapy. However, biocompatible strategies to activate pyroptosis remain rare. Here, we show that a photocatalytic superoxide radical (O 2 –• ) generator, NI-TA , triggers pyroptosis in cancer cells. NI-TA was designed to take advantage of an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed that the pyroptosis triggered by NI-TA under conditions of photoexcitation proceeds through a caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). NI-TA was found to function via a partial-O 2 -recycling mode of action and to trigger cell pyroptosis and provide for effective cancer cell ablation even under conditions of hypoxia (≤2% O 2 ). In the case of T47D 3D …

In situ self-assembly — the in situ formation of complex materials via biochemical reactions of monomers — has enhanced the efficacy of drug delivery for cancer therapy and imaging. So far, nanomedicine has been confined to ex situ self-assembly, which is limited by poor deep-tumour penetration and poor blood circulation. By contrast, in situ self-assembly-based cancer treatments offer various advantages, including enhanced blood circulation of monomers, long-term drug delivery pharmacokinetics, low drug resistance and the ability to target deep tumours and organelles, which can result in disruption-mediated apoptosis and enable the imaging of cellular activity for effective cancer therapy and diagnosis. In this Review, we discuss the design of in situ self-assembled nanomedicines for cancer therapy and imaging based on various endogenous and exogenous stimuli in both the extracellular and the …

Ferroptosis, an iron-dependent programmed cell death mechanism, is regulated by distinct molecular pathways of lipid peroxidation caused by intracellular iron supplementation and glutathione (GSH) synthesis inhibition. It has attracted a great deal of attention as a viable alternative to typical apoptosis-based cancer therapy that exhibits drug resistance. For efficient therapeutic utilization of such a unique and desirable mechanism, precise control using various stimuli to activate the administered nanocarriers is essential. Specific conditions in the tumor microenvironment (e.g., acidic pH, high level of ROS and GSH, hypoxia, etc.) can be exploited as endogenous stimuli to ensure high specificity of the tumor site. Maximized spatiotemporal controllability can be assured by utilizing external energy sources (e.g., magnetic fields, ultrasound, microwaves, light, etc.) as exogenous stimuli that can provide on-demand …

Electrical stimulation can facilitate wound healing with high efficiency and limited side effects. However, current electrical stimulation devices have poor conformability with wounds due to their bulky nature and the rigidity of electrodes utilized. Here, a flexible electrical patch (ePatch) made with conductive hydrogel as electrodes to improve wound management was reported. The conductive hydrogel was synthesized using silver nanowire (AgNW) and methacrylated alginate (MAA), with the former chosen as the electrode material considering its antibacterial properties, and the latter used due to its clinical suitability in wound healing. The composition of the hydrogel was optimized to enable printing on medical-grade patches for personalized wound treatment. The ePatch was shown to promote re-epithelization, enhance angiogenesis, mediate immune response, and prevent infection development in the wound …

Two-dimensional (2D) MXenes are promising as electrode materials for energy storage, owing to their high electronic conductivity and low diffusion barrier. Unfortunately, similar to most 2D materials, MXene nanosheets easily restack during the electrode preparation, which degrades the electrochemical performance of MXene-based materials. A novel synthetic strategy is proposed for converting MXene into restacking-inhibited three-dimensional (3D) balls coated with iron selenides and carbon. This strategy involves the preparation of Fe 2 O 3 @carbon/MXene microspheres via a facile ultrasonic spray pyrolysis and subsequent selenization process. Such 3D structuring effectively prevents interlayer restacking, increases the surface area, and accelerates ion transport, while maintaining the attractive properties of MXene. Furthermore, combining iron selenides and carbon with 3D MXene balls offers many more sites …

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical, biological, and chemical signals to embraced cells. Increasing evidence suggests that mechanical signals derived from the dynamic cellular microenvironment are essential controllers of cell behaviors. Conventional cell culture biomaterials, with static mechanical properties such as chemistry, topography, and stiffness, have offered a fundamental understanding of various vital biochemical and biophysical processes, such as cell adhesion, spreading, migration, growth, and differentiation. At present, novel biomaterials that can spatiotemporally impart biophysical cues to manipulate cell fate are emerging. The dynamic properties and adaptive traits of new materials endow them with the ability to adapt to cell requirements and enhance cell functions. In this review, an introductory overview of the key players essential to …

Light-based phototherapy has been developed for cancer treatment owing to its non-invasiveness and spatiotemporal control. Despite the unique merits of phototherapy, one critical disadvantage of light is its limited penetration depth, which restricts its application in cancer treatment. Although many researchers have developed various strategies to deliver light into deep-seated tumors with two-photon and near-infrared light irradiation, phototherapy encounters the peculiar limitations of light. In addition, high oxygen dependency is another limitation of photodynamic therapy to treat hypoxic tumors. To overcome the drawbacks of conventional treatments, various energy sources have been developed for cancer treatment. Generally, most energy sources, such as ultrasound, chemiluminescence, radiation, microwave, electricity, and magnetic field, are relatively free from the restraint of penetration depth. Combining …

Human induced pluripotent stem cells (hiPSC) are a promising cell source with pluripotency and self-renewal properties. Design of simple and robust biomaterials with an innate ability to induce lineage-specificity of hiPSC is desirable to realize their application in regenerative medicine. In this study, the potential of biomaterials containing calcium phosphate minerals to induce osteogenic differentiation of hiPSC was investigated. hiPSC cultured using mineralized gelatin methacrylate-based matrices underwent osteogenic differentiation ex vivo , in both two-dimensional and three-dimensional cultures, in growth medium devoid of any osteogenic-inducing chemical components or growth factors. The findings that osteogenic differentiation of hiPSC can be achieved through biomaterial-based cues alone present new avenues for personalized regenerative medicine. Such biomaterials that could not only act as …

To improve the quantum efficiency and stability of perovskite quantum dots, the structural and optical properties are optimized by varying the concentration of Ni doping in CsPbBr 3 perovskite nanocrystals (PNCs). As Ni doping is gradually added, a blue shift is observed at the photoluminescence (PL) spectra. Ni‐doped PNCs exhibit stronger light emission, higher quantum efficiency, and longer lifetimes than undoped PNCs. The doped divalent element acts as a defect in the perovskite structure, reducing the recombination rate of electrons and holes. A stability test is used to assess the susceptibility of the perovskite to light and moisture. For ultra‐violet light irradiation, the PL intensity of undoped PNCs decreases by 70%, whereas that of Ni‐doped PNCs decreases by 18%. In the water addition experiment, the PL intensity of Ni‐doped PNCs is three times that of undoped PNCs. For CsPbBr 3 and Ni:CsPbBr 3 PNCs …

One-dimensional (1-D) nanomaterials possess unique shape-dependent phyicochemical properties and are increasingly recognized as promising materials for nanotechnology. 1-D nanomaterials can be classified according to their shape, such as nanorods, nanotubes, nanowires, self-assembled nanochains, etc., and have been applied in electronics, photonics, and catalysis. The biological characteristics of 1-D nanomaterials, including high drug loading efficiency, prolonged blood circulation, the ability to capture cancer cells, unique cellular uptake mechanisms, efficient photothermal conversion, and material tunability, have aided in extending their potential to biomedical applications, particularly in cancer therapy and diagnosis. This review highlights a novel perspective on emerging 1-D nanomaterials for cancer therapy and diagnosis by introducing the definition of 1-D nanomaterials, their shape-dependent …

Osteochondral tissue repair remains a significant challenge in orthopedic surgery. Tissue engineering of osteochondral tissue has transpired as a potential therapeutic solution as it can effectively regenerate bone, cartilage, and the bone-cartilage interface. While advancements in scaffold fabrication and stem cell engineering have made significant progress towards the engineering of composite tissues, such as osteochondral tissue, new approaches are required to improve the outcome of such strategies. Herein, we discuss the use of a single-unit trilayer scaffold with depth-varying pore architecture and mineral environment to engineer osteochondral tissues in vivo . The trilayer scaffold includes a biomineralized bottom layer mimicking the calcium phosphate (CaP)-rich bone microenvironment, a cryogel middle layer with anisotropic pore architecture, and a hydrogel top layer. The mineralized bottom layer was …

Macrophages regulate host responses to implants through their dynamic adhesion, release, and activation. Herein, we employ bisphosphonate (BP)-coated gold nanoparticle template (BNP) to direct the swift and convertible formation of Mg 2+ -functional Mg 2+ -BP nanoparticle (NP) on the BP-AuNP surface via reversible Mg 2+ -BP coordination, thus producing (Mg 2+ -BP)-Au dimer (MgBNP). Ethylenediaminetetraacetic acid-based Mg 2+ chelation facilitates the dissolution of Mg 2+ -BP NP, thus enabling the reversion of the MgBNP to the BNP. This convertible nanoassembly incorporating cell-adhesive Mg 2+ moieties directs reversible attachment and detachment of macrophages by BP and EDTA, without physical scraping or trypsin that could damage cells. The swift formation of RGD ligand- and Mg 2+ -bifunctional RGD-Mg 2+ -BP NP that yields (RGD-Mg 2+ -BP)-Au dimer (RGDBNP) further stimulates the adhesion and …

Mechanical stimulation utilizing deep tissue-penetrating and focusable energy sources, such as ultrasound and magnetic fields, is regarded as an emerging patient-friendly and effective therapeutic strategy to overcome the limitations of conventional cancer therapies based on fundamental external stimuli such as light, heat, electricity, radiation, or microwaves. Recent efforts have suggested that mechanical stimuli-driven cancer therapy (henceforth referred to as “mechanical cancer therapy”) could provide a direct therapeutic effect and intelligent control to augment other anti-cancer systems as a synergistic combinational cancer treatment. This review article highlights the latest advances in mechanical cancer therapy to present a novel perspective on the fundamental principles of ultrasound- and magnetic field-mediated mechanical forces, including compression, tension, shear force, and torque, that can be …

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as a cancer therapy requires a precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, and their use to enhance ferroptosis is indeed a growing area of research. While a few review papers have been published on iron-dependent mechanism and inducers of ferroptosis cancer therapy that partly covers ferroptosis nanoparticles, there is a need for a comprehensive review focusing on the design of magnetic nanoparticles that can typically supply iron ions to promote ferroptosis and simultaneously enable targeted ferroptosis cancer nanomedicine. Furthermore, magnetic nanoparticles can locally induce ferroptosis and combinational ferroptosis with diagnostic magnetic resonance imaging (MRI). The use of remotely controllable …

The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic …

Conventional electronic (e‐) skins are a class of thin‐film electronics mainly fabricated in laboratories or factories, which is incapable of rapid and simple customization for personalized healthcare. Here a new class of e‐tattoos is introduced that can be directly implemented on the skin by facile one‐step coating with various designs at multi‐scale depending on the purpose of the user without a substrate. An e‐tattoo is realized by attaching Pt‐decorated carbon nanotubes on gallium‐based liquid‐metal particles (CMP) to impose intrinsic electrical conductivity and mechanical durability. Tuning the CMP suspension to have low‐zeta potential, excellent wettability, and high‐vapor pressure enables conformal and intimate assembly of particles directly on the skin in 10 s. Low‐cost, ease of preparation, on‐skin compatibility, and multifunctionality of CMP make it highly suitable for e‐tattoos. Demonstrations of electrical …

Macrophages are multifunctional immune cells with diverse physiological functions such as fighting against infection, influencing progression of pathologies, maintaining homeostasis, and regenerating tissues. Macrophages can be induced to adopt distinct polarized phenotypes, such as classically activated pro-inflammatory (M1) phenotypes or alternatively activated anti-inflammatory and pro-healing (M2), to execute diverse and dynamic immune functions. However, unbalanced polarizations of macrophage can lead to various pathologies, such as atherosclerosis, obesity, tumor, and asthma. Thus, the capability to remotely control macrophage phenotypes is important to the success of treating many pathological conditions involving macrophages. In this study, we developed an upconversion nanoparticle (UCNP)-based photoresponsive nanocarrier for near-infrared (NIR) light-mediated control of intracellular …

Extracellular vesicles (e.g., exosomes) carrying various biomolecules (e.g., proteins, lipids, and nucleic acids) have rapidly emerged as promising platforms for many biomedical applications. Despite their enormous potential, their heterogeneity in surfaces and sizes, the high complexity of cargo biomolecules, and the inefficient uptake by recipient cells remain critical barriers for their theranostic applications. To address these critical issues, multifunctional nanomaterials, such as magnetic nanomaterials, with their tunable physical, chemical, and biological properties, may play crucial roles in next‐generation extracellular vesicles (EV)‐based disease diagnosis, drug delivery, tissue engineering, and regenerative medicine. As such, one aims to provide cutting‐edge knowledge pertaining to magnetic nanomaterials‐facilitated isolation, detection, and delivery of extracellular vesicles and their associated biomolecules …

Heemin Kang lab

교수님 소개

강희민, 姜熙敏

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Reversible chemistry for cancer therapy and diagnosis

Covalent Organic Frameworks for Ferroptosis Cancer Therapy

Site-specific transformable nanostructures for cancer therapy and diagnosis

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

강희민, 姜熙敏

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Reversible chemistry for cancer therapy and diagnosis

Covalent Organic Frameworks for Ferroptosis Cancer Therapy

Site-specific transformable nanostructures for cancer therapy and diagnosis

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집