Yeongmok Kim

Woojoo Jeong

Taeyeong An

Jisoo Do

Eunwoo Baek

Jeehee Lee

Welcome! We are Chemical Biology Lab! The combination of chemical precision and biological dynamism, a synergy beyond. Chemical Biology Lab aims for an 'integrated research platform' that encompasses the entire process of new drug development. We provide solutions for next-generation therapeutic development through the perfect harmony of Chemistry and Biology, from the precise synthesis of small molecules and peptides to the multi-faceted efficacy verification based on proteins.

화학적 정밀함과 생물학적 역동성의 결합, 그 이상의 시너지 Chemical Biology Lab은 신약 개발의 전 과정을 아우르는 '통합형 연구 플랫폼’을 지향합니다. 우리는 저분자 화합물과 펩타이드의 정교한 합성부터, 단백질 기반의 다각도 효능 검증까지—Chemistry와 Biology의 완벽한 하모니를 통해 차세대 치료제 개발의 해답을 제시합니다.

Network pharmacology and molecular docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus

Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death

Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

Structure–Activity Relationship of Synthetic Ginkgolic Acid Analogs for Treating Type 2 Diabetes by PTPN9 Inhibition

Site-Selective Antibody–Drug Conjugation by a Proximity-Driven S to N Acyl Transfer Reaction on a Therapeutic Antibody

Terminalin from African Mango (Irvingia gabonensis) Stimulates Glucose Uptake through Inhibition of Protein Tyrosine Phosphatases

Chebulinic Acid Suppresses Adipogenesis in 3T3-L1 Preadipocytes by Inhibiting PPP1CB Activity

Nepetin Acts as a Multi‐Targeting Inhibitor of Protein Tyrosine Phosphatases Relevant to Insulin Resistance

Linoleic acid exerts antidiabetic effects by inhibiting protein tyrosine phosphatases associated with insulin resistance

Eco-friendly synthesis of SnO2-Cu nanocomposites and evaluation of their peroxidase mimetic activity

A FRET‐Based Fluorescent Probe to Screen Anticancer Drugs, Inhibiting p73 Binding to MDM2

Protein tyrosine phosphatases (PTPs) in diabetes: causes and therapeutic opportunities

Metabolite Profile of Cucurbitane-Type Triterpenoids of Bitter Melon (Fruit of Momordica charantia) and Their Inhibitory Activity against Protein Tyrosine Phosphatases Relevant to Insulin Resistance

Phloridzin Acts as an Inhibitor of Protein-Tyrosine Phosphatase MEG2 Relevant to Insulin Resistance

Polyphyllin D Shows Anticancer Effect through a Selective Inhibition of Src Homology Region 2-Containing Protein Tyrosine Phosphatase-2 (SHP2)

Photoconjugation of an Fc-Specific Peptide Enables Efficient DAR 2 Antibody–Drug Conjugate Formation

Identification of Vaccinia‐H1 Related Phosphatase as an Anticancer Target for 1,2,3,4,6‐O‐Pentagalloylglucose

Reclamation of hexavalent chromium using catalytic activity of highly recyclable biogenic Pd (0) nanoparticles

Phytosynthesis of palladium nanoclusters: an efficient nanozyme for ultrasensitive and selective detection of reactive oxygen species

Enzyme mimetic activity of ZnO-Pd nanosheets synthesized via a green route

Facile synthesis of triangular and hexagonal anionic gold nanoparticles and evaluation of their cytotoxicity

Synthesis of Functionalized Silica Particles for Label‐free Detection of PTP1B Using FRET

Chemical constituents of the root bark of Ulmus davidiana var. japonica and their potential biological activities

Biogenic nanomaterials: Site-Selective C–H Alkylation of Diazine N-Oxides Enabled by Phosphonium Ylides

Biogenic nanomaterials: Synthesis, characterization, growth mechanism, and biomedical applications

Ginkgetin, a biflavone from Ginkgo biloba leaves, prevents adipogenesis through STAT5-mediated PPARγ and C/EBPα regulation

Monitoring metal-amyloid-β complexation by a FRET-based probe: design, detection, and inhibitor screening

Sesquiterpenes from Curcuma zedoaria rhizomes and their cytotoxicity against human gastric cancer AGS cells

Fridamycin A, a Microbial Natural Product, Stimulates Glucose Uptake without Inducing Adipogenesis

Identification of chebulinic acid as a dual targeting inhibitor of protein tyrosine phosphatases relevant to insulin resistance

Metal-induced redshift of optical spectra of gold nanoparticles: An instant, sensitive, and selective visual detection of lead ions

Recent Advances in pH-Sensitive Polymeric Nanoparticles for Smart Drug Delivery in Cancer Therapy

Ginkgolic acid as a dual-targeting inhibitor for protein tyrosine phosphatases relevant to insulin resistance, Bioorganic Chemistry

Label-free detection of protein tyrosine phosphatase 1B (PTP1B) using a rationally designed Forster resonance energy transfer (FRET) probe

Identification of sennoside A as a novel inhibitor of the slingshot (SSH) family proteins related to cancer metastasis

Intrinsic Forster resonance energy transfer imaging technique (iFIT) for detection of native protein in live cells

Mitochondria-Targeting Chromogenic and Fluorescence Turn-On Probe for the Selective Detection of Cysteine by Caged Oxazolidinoindocyanine

Cyclic peptide ligand with high binding capacity for affinity purification of immunoglobulin G

Development of Stable Non-Ionic Lipid Nanoparticles

Fc-binding ligands of immunoglobulin G: An overview of high affinity proteins and peptides

Homogeneous detection of caspase-3 using intrinsic fluorescence resonance energy transfer (iFRET)

Stimulation of angiogenesis and survival of endothelial cells by human monoclonal Tie2 receptor antibody

A lactate-induced response to hypoxia

IgG Fc-Binding Peptide (FcBP)-Tat Conjugate as a Smart Antibody Carrier into Live Cells

Phosphoprotein phosphatase 1CB (PPP1CB), a novel adipogenic activator, promotes 3T3-L1 adipogenesis

Functionalized Protein Nanocages as a Platform of Targeted Therapy and Immunodetection

Discovery of coumarin derivatives as acceptors for intrinsic fluorescence resonance energy transfer (iFRET) of proteins

ToF-SIMS analysis of diadenosine triphosphate and didadenosine tetraphosphate using bismuth and argon cluster ion beams

Intrinsic tryptophan fluorescence in the detection and analysis of proteins: a focus on Forster resonance energy transfer techniques

Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates

Recent Advances in Target Characterization and Identification by Photoaffinity Probes

Structural asymmetry of procaspase-7 bound to a specific inhibitor

Chitosan-based intelligent theragnosis nanocomposites enable pH-sensitive drug release with MR-guided imaging for cancer therapy

Fabrication of nanoporous TiO2 hollow capsules using core-shell silica nanoparticle templates

Glyceraldehyde-3-phosphate, a glycolytic intermediate, prevents cells from apoptosis by lowering s-nitrosylation of glyceraldehyde-3-phosphate dehydrogenase

Identification of 3-acyl-2-phenylamino-1,4-dihydroquinolin-4-one derivatives as inhibitors of the phosphatase SerB653 in Porphyromonas gingivalis, implicated in periodontitis

Color-Tunable Photoluminescent Fullerene Nanoparticles

Molecular insight into the role of the leucine residue on the L2 loop in the catalytic activity of caspase-3 and -7

Developing an antibody-binding protein cage as a modular delivery nanoplatform

A selective seoul-fluor-based bioprobe, sfbp, for vaccinia h1-related phosphatase?a dual-specific protein tyrosine phosphatase

Acetylation of malate dehydrogenase 1 promotes adipogenic differentiation via activating its enzymatic activity

Crystal structure of xenotropic murine leukaemia virus-related virus (XMRV) ribonuclease H

A facile synthetic route to diazepinone derivatives via ring closing metathesis and its application for human cytidine deaminase inhibitors

Recent Advances in Protein Tyrosine Phosphatase Detection Using Chemical Probes

Development of PNA-array platforms for detection of genetic polymorphism of cytochrome p450 2c19.

Modulation of exosome-mediated mRNA turnover by interaction of GTP-binding protein 1 (GTPBP1) with its target mRNAs

Photoreversible cellular imaging using photochrome-conjugated fullerene silica nanoparticles.

Brief report: L1 cell adhesion molecule, a novel surface molecule of human embryonic stem cells, is essential for self-renewal and pluripotency

Large-scale expression in Escherichia coli and efficient purification of precursor and active caspase-7 by introduction of thrombin cleavage sites

Enhanced immobilization of hexa-arginine-tagged esterase on gold nanoparticles using mixed self-assembled monolayers

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

Efficient selection of IgG Fc domain-binding peptides fused to fluorescent protein using E. coli Expression system and dot-blotting assay

Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaB transcriptional activity in a Ca(2+)-dependent manner

Proteomic analysis of pancreata from mini-pigs treated with streptozotocin as a type I diabetes models

Real-time colorimetric screening of endopeptidase inhibitors using adenosine triphosphate (ATP)-stabilized gold nanoparticles

An iminocoumarin-based fluorescent probe for the selective detection of dual-specific protein tyrosine phosphatases

Development of a nanoparticle-based FRET sensor for ultrasensitive detection of phytoestrogen compounds

Proteomic analysis of oxidative stress-induced neuronal cell death by using two-dimensional fluorescence difference gel electrophoresis

An ISFET biosensor for the monitoring of maltose-induced conformational changes in MBP

Simultaneous intracellular delivery of targeting antibodies and functional nanoparticles with engineered protein G system

VDUP1 potentiates Ras-mediated angiogenesis via ROS production in endothelial cells

Far upstream element-binding protein-1, a novel caspase substrate, acts as a cross-talker between apoptosis and the c-myc oncogene

An operationally simple colorimetric assay of hyaluronidase activity using cationic gold nanoparticles

Monitoring of Cleavage Preference for Caspase-3 Using Recombinant Protein Substrates

A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

Cascade enzyme-linked immunosorbent assay (CELISA)

Glyceraldehyde-3-phosphate, a glycolytic intermediate, plays a key role in controlling cell fate via inhibition of caspase activity

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites

Characteristics of localized surface plasmon resonance of nanostructured Au patterns for biosensing

Heparin-immobilized pluronic/PVA composite microparticles for the sustained delivery of ionic drug

Controlled antibody immobilization onto immunoanalytical platforms by synthetic peptide

Directed immobilization of DNA-binding proteins on a cognate DNA-modified chip surface

Structure of human alpha-enolase (hENO1), a multifunctional glycolytic enzyme

Identification of proteins binding to decursinol by chemical proteomics

Mixed self-assembly of polydiacetylenes for highly specific and sensitive strip biosensors

, A potent reporter applicable to the monitoring of caspase-3-dependent proteolytic cleavage

Large scale preparation of active caspase-3 in e. coli by designing its thrombin-activatable precursors

Stress-governed expression and purification of human type II hexokinase in Escherichia coli

Reconstruction on the application category of pharmaceutical additives and boundaries of pharmaceutical additives according to the dosage forms

Horseradish peroxidase (HRP) immobilized poly(aniline-co-m-aminophenol) film electrodes-fabrication and evaluation as a hydrogen peroxide sensor

CHUNG, SANGJEON

Professor

CHEMICAL BIOLOGY LAB

교수님 소개

CHUNG, SANGJEON

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Network pharmacology and molecular docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus

Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death

Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

CHUNG, SANGJEON

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Network pharmacology and molecular docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus

Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death

Ethyl Gallate Dual-Targeting PTPN6 and PPARγ Shows Anti-Diabetic and Anti-Obese Effects

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집