Our group focuses on the chemical biology of protein post-translational modifications (PTMs) and their molecular interactions that are relevant in brain and neurological disorders. We integrate chemical, biochemical, structural, and biological approaches such as peptide synthesis, protein engineering, biochemical assays, and cellular experiments to elucidate the functions of chemically modified proteins in vitro and in living cells. Our long-term objective is to identify the specific protein PTMs that drive the progression of brain and neurological diseases and to unravel their underlying molecular mechanisms.

저희 연구실은 뇌 및 신경 질환과 관련된 단백질 번역 후 변형(PTM)의 화학 생물학과 분자 상호작용에 중점을 둡니다. 펩타이드 합성, 단백질 공학, 생화학적 분석 및 세포 실험과 같은 화학적, 생화학적, 구조적, 생물학적 접근 방식을 통합하여 시험관 내 및 살아있는 세포에서 화학적으로 변형된 단백질의 기능을 밝힙니다. 우리의 장기적인 목표는 뇌 및 신경 질환의 진행을 유도하는 특정 단백질 PTM을 식별하고 그 기본 분자 메커니즘을 밝히는 것입니다.

Towards an understanding of amyloid-β oligomers: characterization, toxicity mechanisms, and inhibitors

Link of impaired metal ion homeostasis to mitochondrial dysfunction in neurons

Regulatory Activities of Dopamine and Its Derivatives toward Metal-Free and Metal-Induced Amyloid-β Aggregation, Oxidative Stress, and Inflammation in Alzheimer’s Disease

Mechanistic Insights into Tunable Metal-Mediated Hydrolysis of Amyloid-β Peptides

A PET-based fluorometric chemosensor for the determination of mercury(<scp>ii</scp>) and pH, and hydrolysis reaction-based colorimetric detection of hydrogen sulfide

UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors

Minimalistic Principles for Designing Small Molecules with Multiple Reactivities against Pathological Factors in Dementia

A highly selective fluorescent sensor for the detection of Al3+ and CN− in aqueous solution: biological applications and DFT calculations

Synaptic Copper, Amyloid-β, and Neurotransmitters in Alzheimer’s Disease

A highly selective turn-on chemosensor for Zn2+ in aqueous media and living cells

Converging mechanism of UM171 and KBTBD4 neomorphic cancer mutations

A fluorescent chemosensor for Al3+ based on julolidine and tryptophan moieties

Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease

In Cellulo Mapping of Subcellular Localized Bilirubin

Conformational and functional changes of the native neuropeptide somatostatin occur in the presence of copper and amyloid-β

A zinc fluorescent sensor used to detect mercury (II) and hydrosulfide

Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1

Unveiling the impact of oxidation-driven endogenous protein interactions on the dynamics of amyloid-β aggregation and toxicity

Circular Engineered Sortase for Interrogating Histone H3 in Chromatin

Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring of Amyloid-β Aggregation

Multivalent Interactions Mediate SNAIL Transcription Factor Stimulation of the Nucleosome Deacetylase Activity of the CoREST Complex

Structural Basis of Cooperative COMPASS Activation by Histone Acetylation and Ubiquitination

Histone modification cross-talk: analytical tools and molecular mechanisms

CoREST Complex Inhibition Alters RNA Splicing to Promote Neoantigen Expression and Enhance Tumor Immunity

Interactions with Tau's Microtuble-Binding Repeats Modulate Amyloid-β Aggregation and Toxicity

Structural and Enzymatic Plasticity of SIRT6 Deacylase Activity

UM171 Glues Asymmetric CRL3–HDAC1/2 Assembly to Degrade CoREST Corepressors

Converging Mechanism of UM171 and KBTBD4 Neomorphic Cancer Mutations

Distinct Aggregation Behavior of N-terminally Truncated Aβ4-42 over Aβ1-42 in the Presence of Zn(II)

Uncoupling Histone Modification Crosstalk by Engineering Lysine Demethylase LSD1

APP-C31: An Intracellular Promoter of Both Metal-Free and Metal-Bound Amyloid-β40 Aggregation and Toxicity in Alzheimer's Disease

Dual O2-Mediated Reactivity of a Mononuclear Cobalt Complex with Amyloid-β Peptides

Multifaceted regulation of Sirtuin 2 (Sirt2) Deacetylase Activity

Unveiling the Impact of Oxidation-driven Endogenous Protein Interactions on the Dynamics of Amyloid-β Aggregation and Toxicity

Conformational and Functional Changes of the Native Neuropeptide Somatostatin Occur in the Presence of Copper and Amyloid-β

Distinct Impact of Glycation towards the Aggregation and Toxicity of Murine and Human Amyloid-β

Tunable Regulatory Activities of 1,10-Phenanthroline Derivatives towards Acid Sphingomyelinase and Zn(II)–Amyloid-β

Regulatory Activities of Dopamine and Its Derivatives toward Metal-Free and Metal-Induced Amyloid‑β Aggregation, Oxidative Stress, and Inflammation in Alzheimer’s Disease

Tailoring Hydrophobic Interactions between Probes and Amyloid-β Peptides for Fluorescent Monitoring Amyloid-β Aggregation

Link of Impaired Metal Ion Homeostasis to Mitochondrial Dysfunction in Neurons

Towards an Understanding of Amyloid-β Oligomers: Characterization, Toxicity Mechanisms, and Inhibitors

A Highly Selective Turn-on Chemosensor for Zn(II) in Aqueous Media and Living Cells

Mechanistic Insights into Tunable Metal-mediated Hydrolysis of Amyloid-β Peptides

A Highly Selective Fluorescent Sensor for the Detection of Al(III) and CN− in Aqueous Solution: Biological Applications and DFT Calculations

The Importance of the Dimethylamino Functionality on a Multifunctional Framework for Regulating Metals, Amyloid-β, and Oxidative Stress in Alzheimer’s Disease

In Cellulo Mapping of Subcellular Localized Bilirubin

A Fluorescent Chemosensor for Al(III) Based on Julolidine and Tryptophan Moieties

A PET-based Fluorometric Chemosensor for Determination of Mercury(II) and pH, and Hydrolysis Reaction-based Colorimetric Detection of Hydrogen Sulfide

Eunju Nam

Assistant Professor

Nam Laboratory

교수님 소개

Eunju Nam

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Multivalent Interactions Mediate SNAIL Transcription Factor Stimulation of the Nucleosome Deacetylase Activity of the CoREST Complex

Structural Basis of Cooperative COMPASS Activation by Histone Acetylation and Ubiquitination

Histone modification cross-talk: analytical tools and molecular mechanisms

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

Eunju Nam

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Multivalent Interactions Mediate SNAIL Transcription Factor Stimulation of the Nucleosome Deacetylase Activity of the CoREST Complex

Structural Basis of Cooperative COMPASS Activation by Histone Acetylation and Ubiquitination

Histone modification cross-talk: analytical tools and molecular mechanisms

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집