Na Ly Tran

Ahui Kim

Hyerim Kim

Byoungha Ahn

Cheol-Hee Shin

Choong-Il Lee

In Kyu Lee

Seung Min Kim

The Biomedical Molecular Engineering Laboratory designs and constructs biopharmaceutical platforms and applies them to both understand the molecular biological pathogenesis of various diseases such as cancer and inflammatory diseases and develop therapeutic strategies for them. The lab is currently developing its own therapeutic platforms including CRISPR Self Check-In, mRNA Bridge Mimetics, Epi Activator, and Epi Repressor for curing diseases. We are currently very interested in developing biotherapuetics for treatment of various degenerative diseases.

의생명분자공학 연구실은 생물제약 플랫폼을 설계하고 구축하며, 이를 암 및 염증성 질환과 같은 다양한 질병의 분자 생물학적 병인을 이해하고 치료 전략을 개발하는 데 적용합니다. 연구실은 현재 질병 치료를 위한 CRISPR Self Check-In, mRNA Bridge Mimetics, Epi Activator, Epi Repressor를 포함한 자체 치료 플랫폼을 개발 중입니다. 우리는 현재 다양한 퇴행성 질환 치료를 위한 생물치료제 개발에 매우 관심이 많습니다.

Human opsin restoration by histone methylation using methyltransferase fusion protein SETD7-dCas9

Human Dermal Fibroblast Spheroid Overexpressing Matrix Metalloproteinase-1 Serves as a 3D Platform for In Vitro Drug Screening

Ferroptosis-Mediated Anti-Cancer Activity of Endoperoxide-Containing Steroids Derived from Daedaleopsis confragosa via Targeting NOS2

TRPA1 nanovesicle-conjugated receptonics for rapid biocide screening

A micro-fragmented collagen gel as a cell-assembling platform for critical limb ischemia repair

Exosomal miRNA-29c derived from M1 Macrophages Regulates a Cholesterol Metabolism via Regulation of ENPP2 Expression for Anti-Tumor Efficacy

Effective Protection of Photoreceptors Using an Inflammation-Responsive Hydrogel via Attenuating Inflammatory Activities in Outer Retinal Degenerative Disease

AI-driven New Therapeutic Strategy Targeting STK33 for Cancer Treatment

Eye‐mimicked Neural Network Composed of Photosensitive Neural Spheroids with Human Opsin Proteins

Functionally enhanced cell spheroids for stem cell therapy: Role of TIMP1 in the survival and therapeutic effectiveness of stem cell spheroids

Hydrogel/Nanofiber Composite Wound Dressing Optimized for Skin Layer Regeneration through the Mechanotransduction-Based Microcellular Environme

Soft, Wireless Electronic Dressing System for Wound Analysis and Biophysical Therapy

Facile construction of tumour spheroids with induced M2 macrophage polarization for anticancer drug screening

Fibroblasts Close a Void in Free Space by a Purse-String Mechanism

Cytosolic microRNA-inducible nuclear translocation of Cas9 protein for disease-specific genome modification

On-demand Local Immunomodulation via Epigenetic Control of Macrophages using an Inflammation-responsive Hydrogel for Accelerated Wound Healing

Engineered 3D Multicellular Breast Tumor Spheroid for Drug Screening: A tool for evaluating drug resistance in solid tumors

FGF2-primed 3D spheroids producing IL-8 promote therapeutic angiogenesis in murine hindlimb ischemia

Acetate decreases PVR/CD155 expression via PI3K/ Akt pathway in cancer cells

Exosomal miRNA-19a and miRNA-614 induced by air pollutants promote pro-inflammatory M1 macrophage polarization via regulation of RORα expression in human respiratory mucosal microenvironment

Combinatorial Inhibition of Cell Surface Receptors using Dual Aptamer-functionalized Nanoconstructs for Cancer Treatment

RORα Regulates Cholesterol Metabolism of CD8+ T Cell for Anti-Cancer Immunity

Self-organized Liver Microtissue on a Bio-functional Surface: The Role of Human Adipose-derived Stromal Cells in Hepatic Function

Investigation of the Potential Immunological Effects of Boiling Histotripsy for Cancer Treatment

Machine Learning-Based Design Strategy for 3D-printable Bioink: Elastic Modulus and Yield Stress Determine Printability

Fabrication of 3D Plotted Scaffold With Microporous Strands for Bone Tissue Engineering

Identification of disrupted human airway epithelium by urban particulate matter using respiratory mucosa-on-a-chip

High-intensity Focused Ultrasound-induced Mechanical Ablation (Boiling Histotripsy) modulates Tumor Microenvironment by promoting Immunogenic Cell Death of Cancers

Effect of chain flexibility on cell adhesion: Semi-flexible model-based analysis of cell adhesion to hydrogels

Novel skin patch combining human fibroblast-derived matrix and ciprofloxacin for infected wound healing

Simple in vivo gene editing via direct self-assembly of Cas9 Ribonucleoprotein Complexes for Cancer Treatment

Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities

Synergistic Therapeutic Effect of Three-Dimensional Stem Cell Clusters and Angiopoietin-1 on Promoting Vascular Regeneration in Ischemic Region

Cancer-derived nanovesicles as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

Human lung fibroblast-derived matrix facilitates vascular morphogenesis in 3D environment and enhances skin wound healing

Novel Platform of Cardiomyocyte Culture and Coculture via Fibroblast-Derived Matrix-Coupled Aligned Electrospun Nanofiber

Normalization of Tumor Vessels by Tie2 Activation and Ang2 Inhibition Enhances Drug Delivery and Produces a Favorable Tumor Microenvironment.

Novel strategy for a bispecific antibody: induction of dual target internalization and degradation

Amelioration of Sepsis by Tie2 Activation-Induced Vascular Protection

IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression

Gln-362 of angiopoeitin-2 mediates migration of tumor and endothelial cells through association with "51 integrin

USP8 modulates ubiquitination of LRIG1 for Met degradation

Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors

Phosphoinositide Specificity Determines Which Cytohesins Regulates "1 Integrin Recycling

Differential Effects of cytohesin 2 and 3 on "1 Integrin Recycling

Plastic changes in interhemispheric inhibition with practice of a two-hand force production task: a transcranial magnetic stimulation study

Biomedical Molecular Engineering Lab

교수님 소개

Seung Ja Oh

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Human opsin restoration by histone methylation using methyltransferase fusion protein SETD7-dCas9

Human Dermal Fibroblast Spheroid Overexpressing Matrix Metalloproteinase-1 Serves as a 3D Platform for In Vitro Drug Screening

Ferroptosis-Mediated Anti-Cancer Activity of Endoperoxide-Containing Steroids Derived from Daedaleopsis confragosa via Targeting NOS2

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

Seung Ja Oh

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Human opsin restoration by histone methylation using methyltransferase fusion protein SETD7-dCas9

Human Dermal Fibroblast Spheroid Overexpressing Matrix Metalloproteinase-1 Serves as a 3D Platform for In Vitro Drug Screening

Ferroptosis-Mediated Anti-Cancer Activity of Endoperoxide-Containing Steroids Derived from Daedaleopsis confragosa via Targeting NOS2

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집