Siun Kim

YeSol Hong

HeeJu Kim

Yoomin Jeon

Tae Kyu Chung

Yoona Choi

Seo-rin Choi

Jung-Hyun Won

Seonyeong Oh

Jinyeong Yang

Jun Sik Moon

Suyeon Hong

Duhyeong Lee

Nayoung Ku

Yunha Noh

Yunjin Choi

Aram Kim

Yura Choi

Keun-Ae Song

Sung Jong Kim

Jeong Ah Choi

Chae Jeong Lee

Jung-Chun Gwon

Hyun A Lee

Jeong-An Gim

Soohyun Kim

Heechan Lee

Kyeong-Ryoon Lee

Minyeong Son

Yuchae Jung

The Center for Convergence Approaches in Drug Development (CCADD) seeks to creatively combine and integrate knowledge, ideas, perspectives, insights, tools, and ways of thinking from a myriad of scientific disciplines at their interfaces to solve the most tough challenges that the drug development scientists are facing. CCADD is in the front line to study, invent, apply, and disseminate innovative technologies that can take drug development to a novel scientific venture.

융합적 신약 개발 연구 센터 (CCADD)는 신약 개발 과학자들이 직면한 가장 어려운 과제를 해결하기 위해 다양한 과학 분야의 지식, 아이디어, 관점, 통찰력, 도구 및 사고 방식을 창의적으로 결합하고 통합하고자 합니다. CCADD는 신약 개발을 새로운 과학적 벤처로 이끌 수 있는 혁신적인 기술을 연구, 발명, 적용 및 보급하는 데 앞장서고 있습니다.

Beyond Fine-Tuning: Leveraging Domain-Aware In-Context learning with large language models for clinical named entity recognition

A Comparison of AI and Population PK Models to Predict the Concentrations of Antiepileptic Drugs Using Therapeutic Drug Monitoring Records

First-In-Human Study of Safety, Tolerability, Efficacy, and Pharmacolkinetics of CPNE7-Derived Peptide (Selcopintide) for Dentin Hypersensitivity

Improving ACS prediction in T2DM patients by addressing false records in electronic medical records using propensity score

Dose Optimization of rhIL-7-hyFc for Patients With Lymphopenia Using a Neonatal Fc Receptor-Mediated Recycling-Based and Target-Mediated Drug Disposition Pharmacokinetic Model

Country Contribution to Investigators of Pivotal Clinical Trials and their Primary Publications of New Drugs Approved by the US Food and Drug Administration, 2012–2021

Effect of Narrowband Ultraviolet B Phototherapy on Systemic Metabolome in Korean Patients with Psoriasis

Metabolic profiling of psoriasis vulgaris and palmoplantar pustulosis

Developing Machine Learning Model for Predicting Acute Coronary Syndrome in Type 2 Diabetes Mellitus Patients through Substitution of Propensity Scores for Binary Variables

One-year Post-Acute COVID-19 Syndrome and Mortality in South Korea: A Nationwide Matched Cohort Study Using Claims Data

A Study to Evaluate the Effectiveness and Safety of Prephase Steroid Treatment before Remission Induction Chemotherapy in Patients with Pediatric Acute Lymphoblastic Leukemia Using Common Data Model-Based Real-World Data: A Retrospective Observational Study

A Phase Ib/2a Study of GC1118 with 5-Fluorouracil, Leucovorin and Irinotecan (FOLFIRI) in Patients with Recurrent or Metastatic Colorectal Cancer

Understanding the pharmacokinetic journey of Fc-fusion protein, rhIL-7-hyFc, using complementary approach of two analytical methods, accelerator mass spectrometry and ELISA

CReSE: Benchmark Data and Automatic Evaluation Framework for Recommending Eligibility Criteria from Clinical Trial Information

Country contribution of investigators to pivotal clinical trials and their primary publications of new oncology drugs approved by the US Food and Drug Administration

A Study to Evaluate the Effectiveness and Safety of Prephase Steroid Treatment before Remission Induction Chemotherapy in Patients with Pediatric Acute Lymphoblastic Leukemia Using Common Data Model-Based Real World Data

Effectiveness and Safety of Sodium-Glucose Cotransporter 2 Inhibitors Added to Dual or Triple Treatment in Patients with Type 2 Diabetes Mellitus

Trends in medical care utilization in patients with cancer: An analysis of real-world data in a tertiary hospital in Korea, 2014–2019

[합성의약품 시대는 가고]바이오의약품 시대가 온다. 개정증보판

Automatic Extraction of Comprehensive Drug Safety Information from Adverse Drug Event Narratives in the Korea Adverse Event Reporting System Using Natural Language Processing Techniques

Clinical Characteristics Associated with Adherence and Persistence in Patients with Type 2 Diabetes Mellitus Treated with Dulaglutide

Revisiting Machine-Learning based Drug Repurposing: Drug Indications Are Not a Right Prediction Target

A single administration of hIL-7-hyFc induces long-lasting T-cell expansion with maintained functions and TCR diversity

How to boost and accelerate new drug development in Korea: business ecosystem perspectives

Factors affecting the changes in antihypertensive medications in patients with hypertension

Machine learning-based quantitative prediction of drug exposure in drug-drug interactions using drug label information

A population PK-PD model of YH4808, a novel P-CAB, and intragastric pH that incorporated negative feedback by increased intragastric pH onto the systemic exposure to YH4808

『대한민국 신약개발 성공전략』

개인맞춤형 건강기능식품 추천용 설문지 개발

Clinical Response and Hospital Costs of Therapeutic Drug Monitoring for Vancomycin in Elderly Patients

Adherence and persistence rates of major antidibetic medications: a review

An annotated corpus from biomedical articles to construct a drug-food interaction database

A Randomized, Double-Blind, Placebo- and Active-Controlled, Escalating Single-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetic, Pharmacodynamic Profiles of Subcutaneous Eflapegrastim in Healthy Japanese and Caucasian Subjects

『K-방역은 없다』

A double-blind, placebo-controlled, single-ascending dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of HM15136, a novel long-acting glucagon analogue, in healthy subjects

신약개발을 위한 제약바이오산업 생태계 분석과 정책 제안

A phase I study to evaluate the safety, tolerability, pharmacodynamic and pharmacokinetic profiles of ocular GLH8NDE in healthy male subjects

A population pharmacokinetic-pharmacodynamic model of YH12852, a highly selective 5-hydroxytryptamine 4 receptor agonist, in healthy subjects and patients with functional constipation

Tissue pharmacokinetics of DHP107, a novel lipid‐based oral formulation of paclitaxel, in mice and patients by positron emission tomography

Can the COVID-19 Pandemic Disrupt the Current Drug Development Practices?

Pharmacokinetics and tolerability of apremilast in healthy Korean adult men

Policy Suggestions to Improve Patient Access to New Drugs in Korea

A Target-Mediated Drug Disposition Population Pharmacokinetic Model of GC1118, a Novel Anti-EGFR Antibody, in Patients with Solid Tumors

The Current Status of Drug Repositioning and Vaccine Developments for the COVID-19 Pandemic

YH12852, a Potent and Selective Receptor Agonist of 5-hydroxytryptamine, Increased Gastrointestinal Motility in Healthy Volunteers and Patients with Functional Constipation

임상시험의 효율적 디자인, 시뮬레이션, 사전 예측을 위한 HIRA 빅데이터 활용 가능성

Development of a Pharmacokinetic Model Describing FcRn-Mediated Recycling of HL2351,
a Novel Hybrid Fc-Fused IL1Ra, to Optimize Dosage Regimen

An investigation of the metabolism and excretion of KD101 and its inter-individual differences: a microtracing mass balance study in humans

환자의 신약 접근성을 강화하기 위한 정책 제안

A
critical review of the United States regulatory pathways for determining the equivalence
of efficacy between CT-P13 and original infliximab (Remicade ®)

Scientific considerations for global drug development

Common data model-based real-world data for practical clinical practice guidelines: clinical pharmacology perspectives

Phase 1 study of CWP232291 in patients with relapsed or refractory acute myeloid leukemia and myelodysplastic syndrome

A physiologically-based pharmacokinetic model adequately predicted the human pharmacokinetic profiles of YH4808, a novel K+-competitive acid blocker’

Suboptimal aminoglycoside dosing in critically ill patients

Postmarketing drug dosage changes of 499 FDA‐approved new molecular entities, 1980–1999

Population pharmacokinetic and pharmacodynamic modeling of etanercept using logistic regression analysis

Population pharmacokinetics of golimumab, an anti‐tumor necrosis factor‐α human monoclonal antibody, in patients with psoriatic arthritis

Is extrapolation of the safety and efficacy data in one indication to another appropriate for biosimilars?

Population pharmacokinetic analysis and simulation of the time‐concentration profile of etanercept in pediatric patients with juvenile rheumatoid arthritis

A Pharmacokinetic‐pharmacodynamic Model for the Mobilization of CD34 + Hematopoietic Progenitor Cells by AMD3100

Adherence and persistence rates of major antidiabetic medications: a review

Simulation of correlated continuous and categorical variables using a single multivariate distribution

The current status of drug repositioning and vaccine developments for the COVID-19 pandemic

Clonidine clearance matures rapidly during the early postnatal period: a population pharmacokinetic analysis in newborns with neonatal abstinence syndrome

Population pharmacokinetics of golimumab in patients with ankylosing spondylitis: impact of body weight and immunogenicity.

Safety, tolerability, pharmacokinetics, and pharmacodynamics of fimasartan following single and repeated oral administration in the fasted and fed states in healthy subjects

Effects of proton pump inhibitors on metformin pharmacokinetics and pharmacodynamics

What does it take to make model-informed precision dosing common practice? Report from the 1st Asian symposium on precision dosing

A thorough QT study to evaluate the QTc prolongation potential of two neuropsychiatric drugs, quetiapine and escitalopram, in healthy volunteers

hIL‐7‐hyFc, a long‐acting IL‐7, increased absolute lymphocyte count in healthy subjects

Determination of the starting dose in the first-in-human clinical trials with monoclonal antibodies: a systematic review of papers published between 1990 and 2013

Howard Lee

Assistant professor of Medicine, later, director of CDDS

Taught at the University of California San Francisco and the University of Pittsburgh

CCADD

교수님 소개

이형기

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Beyond Fine-Tuning: Leveraging Domain-Aware In-Context learning with large language models for clinical named entity recognition

A Comparison of AI and Population PK Models to Predict the Concentrations of Antiepileptic Drugs Using Therapeutic Drug Monitoring Records

First-In-Human Study of Safety, Tolerability, Efficacy, and Pharmacolkinetics of CPNE7-Derived Peptide (Selcopintide) for Dentin Hypersensitivity

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

이형기

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Beyond Fine-Tuning: Leveraging Domain-Aware In-Context learning with large language models for clinical named entity recognition

A Comparison of AI and Population PK Models to Predict the Concentrations of Antiepileptic Drugs Using Therapeutic Drug Monitoring Records

First-In-Human Study of Safety, Tolerability, Efficacy, and Pharmacolkinetics of CPNE7-Derived Peptide (Selcopintide) for Dentin Hypersensitivity

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집