The image artistically illustrates the age-dependent maturation of corticothalamic circuits and its impact on sensory discriminability as discussed by Lee, Han, et al. in this issue of Neuron. The juxtaposed faces of a juvenile and an adult symbolize maturation stages, with overlaid neural networks highlighting the transition from robust juvenile corticothalamic inputs to refined adult connectivity amid a complex extracellular environment. The evolving background landscapes represent the progressive enhancement of sensory acuity through maturation. Together, these elements visualize the structural and environmental shifts that underpin the developmental refinement of sensory perception. Image created by Jin Joo Yang, CEO, Science Note.

이 이미지는 Lee, Han 등 이 Neuron의 이번 호에서 논의한 피질-시상 회로의 연령 의존적 성숙과 감각 변별력에 미치는 영향을 예술적으로 보여줍니다. 소아와 성인의 얼굴이 나란히 배치되어 성숙 단계를 상징하며, 중첩된 신경망은 복잡한 세포외 환경 속에서 견고한 소아 피질-시상 입력에서 정교한 성인 연결로의 전환을 강조합니다. 진화하는 배경 풍경은 성숙을 통해 감각 예민도가 점진적으로 향상됨을 나타냅니다. 이 모든 요소들은 감각 인식의 발달적 정교화를 뒷받침하는 구조적 및 환경적 변화를 시각화합니다. 이미지 제작: 진주양, CEO, Science Note.

LRRTM2 functions as a neurexin ligand in promoting excitatory synapse formation

Neuroanatomical substrates of rodent social behavior: the medial prefrontal cortex and its projection patterns

Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases

Association of the kinesin motor KIF1A with the multimodular protein liprin-α

High affinity neurexin binding to cell adhesion G-protein-coupled receptor CIRL1/latrophilin-1 produces an intercellular adhesion complex

Interaction of the ERC family of RIM-binding proteins with the liprin-α family of multidomain proteins

Gephyrin: a central GABAergic synapse organizer

A neuroligin-4 missense mutation associated with autism impairs neuroligin-4 folding and endoplasmic reticulum export

Neurexins physically and functionally interact with GABAA receptors

Slitrks control excitatory and inhibitory synapse formation with LAR receptor protein tyrosine phosphatases

Interaction between liprin-α and GIT1 is required for AMPA receptor targeting

LAR-RPTPs: synaptic adhesion molecules that shape synapse development

The GIT family of proteins forms multimers and associates with the presynaptic cytomatrix protein Piccolo

An autism-associated point mutation in the neuroligin cytoplasmic tail selectively impairs AMPA receptor‐mediated synaptic transmission in hippocampus

SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses

Neuroligin-1 performs neurexin-dependent and neurexin-independent functions in synapse validation

Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95

MDGAs interact selectively with neuroligin-2 but not other neuroligins to regulate inhibitory synapse development

The neurexin ligands, neuroligins and leucine-rich repeat transmembrane proteins, perform convergent and divergent synaptic functions in vivo

Structural basis for LAR-RPTP/Slitrk complex-mediated synaptic adhesion

Rethinking two-photon voltage imaging

Honeybee GABA A receptor structure informs new insecticide development

Feature-tuned excitation of somatostatin interneurons drives figure-ground segregation

When breaking down helps you move forward: Pursuing complex goals

Ennio Pannese (1928–2025)

A population approach to cortical GABAergic interneuron function

Granular motivational interaction and behavioral choice during feeding

Two-photon voltage imaging with rhodopsin-based sensors

Developmental reprogramming in melanocortin neurons modulates diet-induced obesity in mice

Juvenile-to-adult refinement of thalamic reticular circuits via LRRTM3 enables high-resolution sensory encoding

Structures of the honeybee GABA A RDL receptor illuminate allosteric modulation

Neuronal spiking in the mammalian forebrain is dominated by a heterogeneous ground state

Feature-tuned synaptic inputs to somatostatin interneurons drive context-dependent processing

Low-intensity focused ultrasound to human amygdala reveals a causal role in ambiguous emotion processing and alters local and network activity

Temporal-orbitofrontal pathway regulates choices across physical reward and visual novelty

The representation and valuation of subgoals in the human brain during model-based hierarchical behavior

The layer 6b theory of attention

Jaewon Ko

Professor

Jaewon Ko Laboratory

교수님 소개

Jaewon Ko

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Rethinking two-photon voltage imaging

Honeybee GABA A receptor structure informs new insecticide development

Feature-tuned excitation of somatostatin interneurons drives figure-ground segregation

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

Jaewon Ko

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Rethinking two-photon voltage imaging

Honeybee GABA A receptor structure informs new insecticide development

Feature-tuned excitation of somatostatin interneurons drives figure-ground segregation

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집