Welcome to Hong Lab for Immune Cell Biology. Join us as we explore cutting-edge science to unravel the complexities of the immune system! At our lab, we delve into the fascinating world of the adaptive immune system, focusing on the immune responses of T cells and B cells. Our primary goal is to uncover the mysteries of immune tolerance—a critical process that prevents strong immune reactions against everyday antigens, including self-antigens, food antigens, and foreign antigens like commensal microbes. Building on this understanding, we seek to elucidate the mechanisms behind diseases that arise from the breakdown of immune tolerance to these antigens, such as allergies, inflammatory bowel diseases, and autoimmune diseases, and to propose new therapeutic approaches.

저희 연구실은 적응 면역계의 주요 세포인 T cell과 B cell의 면역 반응에 대하여 연구합니다. 항상 노출되고 있는 항원 종류인 자가 항원과 음식 항원 및 공생 세균을 포함하는 외부 항원에 대하여 강한 면역 반응을 유발하지 않는 현상인 면역 관용을 이해하는 연구를 합니다. 이를 바탕으로, 알레르기, 염증성 장질환, 자가면역질환과 같이 위의 항원에 대한 면역 관용이 유지되지 않아 발생하는 질병들의 발병 기전을 규명하고 새로운 치료 방법을 제시하고자 합니다.

Measurement of the properties of a Higgs boson in the four-lepton final state

Paramagnetic Ultrasmall Gadolinium Oxide Nanoparticles as Advanced T1 MRI Contrast Agent: Account for Large Longitudinal Relaxivity, Optimal Particle Diameter, and In Vivo T1 MR Images

Internet traffic classification demystified

Search for dark matter, extra dimensions, and unparticles in monojet events in proton–proton collisions at $$\sqrt{s} = 8$$ s = 8 $$\,{\mathrm{TeV}}\,$$ TeV

Measurement of Higgs boson production and properties in the WW decay channel with leptonic final states

Searches for electroweak production of charginos, neutralinos, and sleptons decaying to leptons and W, Z, and Higgs bosons in pp collisions at 8 TeV

Search for new physics in the multijet and missing transverse momentum final state in proton-proton collisions at $ \sqrt{s} $ = 8 TeV

Evidence for the 125 GeV Higgs boson decaying to a pair of τ leptons

1,1'-Bis(alkylarylphosphino)ferrocenes: synthesis, metal complex formation, and crystal structure of three metal complexes of Fe(.eta.5-C5H4PPh2)2

Search for invisible decays of Higgs bosons in the vector boson fusion and associated ZH production modes

Measurement of jet fragmentation in PbPb and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>p</mml:mi><mml:mi>p</mml:mi></mml:mrow></mml:math>collisions at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:msub><mml:mi>s</mml:mi><mml:mi mathvariant="italic">NN</mml:mi></mml:msub></mml:msqrt><mml:mo>=</mml:mo><mml:mn>2.76</mml:mn></mml:mrow></mml:math>TeV

Inclusive search for a vector-like T quark with charge <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:mfrac><mml:mn>2</mml:mn><mml:mn>3</mml:mn></mml:mfrac></mml:math> in pp collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si2.gif" overflow="scroll"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>8</mml:mn><mml:mtext> </mml:mtext><mml:mtext>TeV</mml:mtext></mml:math>

Measurement of higher-order harmonic azimuthal anisotropy in PbPb collisions at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:msub><mml:mi>s</mml:mi><mml:mi mathvariant="italic">NN</mml:mi></mml:msub></mml:msqrt><mml:mo>=</mml:mo><mml:mn>2.76</mml:mn></mml:mrow></mml:math>TeV

Search for massive resonances in dijet systems containing jets tagged as W or Z boson decays in pp collisions at s $$ \sqrt{s} $$ = 8 TeV

Search for massive resonances decaying into pairs of boosted bosons in semi-leptonic final states at s $$ \sqrt{s} $$ = 8 TeV

Observation of the Associated Production of a Single Top Quark and a<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>W</mml:mi></mml:math>Boson in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>p</mml:mi><mml:mi>p</mml:mi></mml:math>Collisions at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msqrt><mml:mrow><mml:mi>s</mml:mi></mml:mrow></mml:msqrt><mml:mo>=</mml:mo><mml:mn>8</mml:mn><mml:mtext> </mml:mtext><mml:mtext> </mml:mtext><mml:mi>TeV</mml:mi></mml:mrow></mml:math>

Potential dual imaging nanoparticle: Gd2O3 nanoparticle

Paramagnetic nanoparticle T1 and T2 MRI contrast agents

A Facile Synthesis, In vitro and In vivo MR Studies of <scp>d</scp>-Glucuronic Acid-Coated Ultrasmall Ln2O3 (Ln = Eu, Gd, Dy, Ho, and Er) Nanoparticles as a New Potential MRI Contrast Agent

Measurement of the muon charge asymmetry in inclusive<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mi>p</mml:mi><mml:mi>p</mml:mi><mml:mo stretchy="false">→</mml:mo><mml:mi>W</mml:mi><mml:mo>+</mml:mo><mml:mi>X</mml:mi></mml:mrow></mml:math>production at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msqrt><mml:mrow><mml:mi>s</mml:mi></mml:mrow></mml:msqrt><mml:mo>=</mml:mo><mml:mn>7</mml:mn><mml:mtext> </mml:mtext><mml:mtext> </mml:mtext><mml:mi>TeV</mml:mi></mml:mrow></mml:math>and an improved determination of light parton distribution functions

Novel insights into T cell exhaustion in chronic viral infections

Targeting myeloid-derived suppressor cells for enhanced cancer immunotherapy

Role of regulatory B cells in autoimmune disease progression

Perilla frutescens Britton var. acuta Kudo ameliorates OVA-induced allergic asthma via inhibiting NF-κB and p38 signaling pathways

Immune tolerance to foreign antigens in the intestine: mechanisms mediated by CD4+ T cells

A minority of Th1 and Tfh effector cells express survival genes shared by memory cell progeny that require IL-7 or TCR signaling to persist

Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction

Dietary antigens suppress the proliferation of type 2 innate lymphoid cells by restraining homeostatic IL-25 production

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

Listeria monocytogenes Establishes Commensalism in Germ-Free Mice Through the Reversible Downregulation of Virulence Gene Expression

Two sequential activation modules control the differentiation of protective T helper-1 (Th1) cells

Cutting Edge: Mouse SARS-CoV-2 Epitope Reveals Infection and Vaccine-Elicited CD8 T Cell Responses

Dietary Glucose Consumption Promotes RALDH Activity in Small Intestinal CD103+CD11b+ Dendritic Cells

Hybrid Fc‐fused interleukin‐7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy

Interleukin-2/antibody complex expanding Foxp3+ regulatory T cells exacerbates Th2-mediated allergic airway inflammation

Food antigens drive spontaneous IgE elevation in the absence of commensal microbiota

Hong Lab

교수님 소개

홍성욱

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Novel insights into T cell exhaustion in chronic viral infections

Targeting myeloid-derived suppressor cells for enhanced cancer immunotherapy

Role of regulatory B cells in autoimmune disease progression

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

홍성욱

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Novel insights into T cell exhaustion in chronic viral infections

Targeting myeloid-derived suppressor cells for enhanced cancer immunotherapy

Role of regulatory B cells in autoimmune disease progression

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집