Deciphering and exploiting cancer-specific alterations to improve cancer therapy


The intricate interplay between genetic and epigenetic pathways assumes pivotal roles in governing both normal and malignant cellular development and function. Then, how do alterations in the epigenetic landscape disturb the barrier between normal and malignant states, ultimately leading to the development of diseases such as cancers? How can we translate these disease-specific aberrations into more efficient therapeutic strategies? These are two overarching questions that our current research endeavors revolve around.

생체 내 암 발생 원리 규명
세포의 정상 분화 및 암화의 조절 메커니즘 규명
암특이적인 변이를 표적으로 하는 새로운 표적항암제 개발
비만, 당뇨, 간질환 등 대사질환의 후생유전학적 조절 및 암과의 상관성


줄기세포 노화, 염증, 그리고 각종 노화 연관 대사질환

생체 내 암 발생 원리 규명
세포의 정상 분화 및 암화의 조절 메커니즘 규명
암특이적인 변이를 표적으로 하는 새로운 표적항암제 개발
비만, 당뇨, 간질환 등 대사질환의 후생유전학적 조절 및 암과의 상관성


줄기세포 노화, 염증, 그리고 각종 노화 연관 대사질환

Portable and wireless DNA nanosensor for early detection of lung cancer using ultrafast synthesis of 1T-MoS2/liposome-AuNP modified transducer

Portable, wireless potentiostat sensor for ultra-sensitive, real-time detection of 5hmC in genomic DNA using tree-like graphene

Proteomic profiling of exosomes leads to the identification of a candidate biomarker for prostate cancer progression

Editorial for the Special Issue "Molecular Mechanisms of Leukemia"

Ultrasensitive detection of 5-hydroxymethylcytosine in genomic DNA using a graphene-based sensor modified with biotin and gold nanoparticles

TET enzymes in the immune system: from DNA demethylation to immunotherapy, inflammation, and Cancer

Development of Novel Epigenetic Anti-Cancer Therapy Targeting TET Proteins

Pharmacological GLUT3 salvage augments the efficacy of vitamin C-induced TET2 restoration in acute myeloid leukemia

Highly selective and real-time detection of 5-hydroxymethylcytosine in genomic DNA using a carbon nitride-modified gold transducer-based electrochemical sensor

Epigenetic regulators of DNA cytosine modification: Promising targets for cancer therapy

Inducible disruption of Tet genes results in myeloid malignancy, readthrough transcription, and a heterochromatin-to-euchromatin switch

Epigenetic modification of cytosines in hematopoietic differentiation and malignant transformation

Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression

BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells

A fast and label-free detection of hydroxymethylated DNA using a nozzle-jet printed AuNPs@Ti3C2 MXene-based electrochemical sensor

Rapid and Label-Free Detection of 5-Hydroxymethylcytosine in Genomic DNA Using an Au/ZnO Nanorods Hybrid Nanostructure-Based Electrochemical Sensor

Direct and rapid detection of 5-hydroxymethylcytosine, a novel cancer hallmark in DNA, using electrochemical reaction

Decoding ribosomes to keep growing (in AML)

TET family dioxygenases and DNA demethylation in stem cells and cancers

DNA Demethylation of the Foxp3 Enhancer Is Maintained through Modulation of Ten-Eleven-Translocation and DNA Methyltransferases

DNMT3A and TET2 compete and cooperate to repress lineage-specific transcription factors in hematopoietic stem cells

TET2 regulates mast cell differentiation and proliferation through catalytic and non-catalytic activities

Acute loss of TET function results in aggressive myeloid cancer in mice

DNA methylation and hydroxymethylation in hematologic differentiation and transformation

Functions of TET proteins in hematopoietic transformation

A zebrafish model of myelodysplasia produced through tet2 genomic editing

TET proteins and 5-methylcytosine oxidation in hematological cancers

Large conserved domains of low DNA methylation maintained by 5-hydroxymethycytosine and Dnmt3a

Modulation of TET2 expression and 5-methylcytosine oxidation by the CXXC domain protein IDAX

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

The SWI/SNF-like BAF complex is essential for early B cell development

TET2: epigenetic safeguard for HSC

Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

Srg3, a mouse homolog of BAF155, is a novel p53 target and acts as a tumor suppressor by modulating p21WAF1/CIP1 expression

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Chromatin remodeling, development and disease

Baf60a interacts with p53 to recruit the SWI/SNF complex

Expression of SRG3, a core component of mouse SWI/SNF chromatin-remodeling complex, is regulated by cooperative interactions between Sp1/Sp3 and Ets transcription factors

Modulation of androgen receptor transactivation by the SWI3-related gene product (SRG3) in multiple ways

T-cell receptor signaling inhibits glucocorticoid-induced apoptosis by repressing the SRG3expression via Ras activation

E2A/HEB and Id3 proteins control the sensitivity to glucocorticoid-induced apoptosis in thymocytes by regulating the SRG3 expression

Rescuing developing thymocytes from death by neglect

Peripheral T cells become sensitive to glucocorticoid- and stress-induced apoptosis in transgenic mice overexpressing SRG3

Myunggon Ko

Associate Professor

Molecular Immunology & Cancer Epigenetics Laboratory

교수님 소개

고명곤

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Portable and wireless DNA nanosensor for early detection of lung cancer using ultrafast synthesis of 1T-MoS2/liposome-AuNP modified transducer

Portable, wireless potentiostat sensor for ultra-sensitive, real-time detection of 5hmC in genomic DNA using tree-like graphene

Proteomic profiling of exosomes leads to the identification of a candidate biomarker for prostate cancer progression

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

고명곤

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Portable and wireless DNA nanosensor for early detection of lung cancer using ultrafast synthesis of 1T-MoS2/liposome-AuNP modified transducer

Portable, wireless potentiostat sensor for ultra-sensitive, real-time detection of 5hmC in genomic DNA using tree-like graphene

Proteomic profiling of exosomes leads to the identification of a candidate biomarker for prostate cancer progression

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집