We are a young bioorganic chemistry & chemical biology research group at UNIST. 우리 연구실에서는 저분자 물질에서 펩타이드, 합성단백질에 이르는 다양한 유기분자를 설계 및 합성하는 유기합성화학 연구 및 이를 활용한 학제적 화학생물학 연구를 진행하고 있습니다. 또한 이러한 분자 도구를 이용하여, 단백질의 다양한 번역후 수식 (posttranslational modifications)를 연구하고 있습니다. 특히 항암제 및 차세대 항생제의 타겟이 되는 여러 인산화효소 및 탈인산화효소의 기능을 연구하고, 이를 저해하는 신약 후보물질을 발굴하는 연구 또한 진행하고 있습니다. 유기합성화학, 단백질화학, 화학생물학에 관심있는 학부생/대학원생/연구원의 문의 및 참여를 환영합니다.

우리 연구실에서는 저분자 물질에서 펩타이드, 합성단백질에 이르는 다양한 유기분자를 설계 및 합성하는 유기합성화학 연구 및 이를 활용한 학제적 화학생물학 연구를 진행하고 있습니다. 또한 이러한 분자 도구를 이용하여, 단백질의 다양한 번역후 수식 (posttranslational modifications)를 연구하고 있습니다. 특히 항암제 및 차세대 항생제의 타겟이 되는 여러 인산화효소 및 탈인산화효소의 기능을 연구하고, 이를 저해하는 신약 후보물질을 발굴하는 연구 또한 진행하고 있습니다. 유기합성화학, 단백질화학, 화학생물학에 관심있는 학부생/대학원생/연구원의 문의 및 참여를 환영합니다.

Proteomic Profiling of Oxidative Stress Response Proteins with a Methionine Sulfoxide-Inspired Activity-Based Probe

Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes

Chemoproteomic identification of phosphohistidine acceptors: posttranslational activity regulation of a key glycolytic enzyme

Bringing Histidine Phosphorylation into Light: Role of Chemical Tools

AI is a viable alternative to high throughput screening: a 318-target study

Identification of a Target Site for Covalent Inhibition of Protein Phosphohistidine Phosphatase 1

A Simple Protein Histidine Kinase Activity Assay for High-throughput Inhibitor Screening

Ir and NHC Dual Chiral Synergetic Catalysis: Mechanism and Stereoselectivity in γ-Butyrolactone Formation

Quest for the Crypto-proteome

Distinct Reaction Dynamics of Protein Arginine Kinases Revealed by Fluorescent Activity Probes

Chemoselective Trifluoroethylation Reactions of Quinazolinones and Identification of Photostability

A specific fluorescent probe for protein histidine phosphatase activity

Recent Updates on Protein N-Phosphoramidate Hydrolases

Sequence-dependent DNA condensation as a driving force of DNA phase separation

Nickel-Catalyzed Azide-Alkyne Cycloaddition to Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water.

Direct Diversification of Unmasked Quinazolin-4(3H)-Ones Through Orthogonal Reactivity Modulation.

Bisphosphoglycerate Mutase Controls Serine Pathway Flux via 3-Phosphoglycerate

A Second-Generation Phosphohistidine Analog for Production of Phosphohistidine Antibodies

Function through Bio-Inspired, Synthesis-Informed Design: Step-Economical Syntheses of Designed Kinase Inhibitors

A Phosphohistidine Proteomics Strategy Based on Elucidation of a Unique Gas-phase Phosphopeptide Fragmentation Mechanism

A Pan-specific Antibody for Direct Detection of Protein Histidine Phosphorylation

Chasing Phosphohistidine, An Elusive Sibling in the Phosphoamino Acid Family

Gateway Synthesis of Daphnane Congeners and their Protein Kinase C Affinities and Cell-growth Activities

Development of Stable Phosphohistidine Analogues

Practical Synthesis of Prostratin, DPP, and their Analogs, Adjuvant Leads against Latent HIV

The Stereoselective Dimerization Reaction of Oxidopyrylium Ions

Studies on Oxidopyrylium [5+2] Cycloadditions: Towards a General Synthetic Route to the C12-Hydroxy Daphnetoxins

Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV

Development of stable phosphohistidine analogues

Nickel-Catalyzed Azide–Alkyne Cycloaddition To Access 1,5-Disubstituted 1,2,3-Triazoles in Air and Water

A pan-specific antibody for direct detection of protein histidine phosphorylation

Chasing phosphohistidine, an elusive sibling in the phosphoamino acid family

Gateway synthesis of daphnane congeners and their protein kinase C affinities and cell-growth activities

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate

A phosphohistidine proteomics strategy based on elucidation of a unique gas-phase phosphopeptide fragmentation mechanism

Studies on oxidopyrylium [5+ 2] cycloadditions: toward a general synthetic route to the C12-hydroxy daphnetoxins

A second-generation phosphohistidine analog for production of phosphohistidine antibodies

Direct diversification of unmasked quinazolin-4 (3 H)-ones through orthogonal reactivity modulation

Specific fluorescent probe for protein histidine phosphatase activity

Ir and NHC dual chiral synergetic catalysis: mechanism and stereoselectivity in γ-butyrolactone formation

Recent Updates on Protein N ‐Phosphoramidate Hydrolases

Distinct phosphorylation and dephosphorylation dynamics of a protein arginine kinase revealed by fluorescent activity probes

The stereoselective dimerization reaction of oxidopyrylium ions

Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors

THE KEE LAB

교수님 소개

기정민

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Proteomic Profiling of Oxidative Stress Response Proteins with a Methionine Sulfoxide-Inspired Activity-Based Probe

Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes

Chemoproteomic identification of phosphohistidine acceptors: posttranslational activity regulation of a key glycolytic enzyme

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

기정민

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Proteomic Profiling of Oxidative Stress Response Proteins with a Methionine Sulfoxide-Inspired Activity-Based Probe

Intracristal space proteome mapping using super-resolution proximity labeling with isotope-coded probes

Chemoproteomic identification of phosphohistidine acceptors: posttranslational activity regulation of a key glycolytic enzyme

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집