위춘화

팜녹첸

전정이

류선영

전태진

남경태

박소야

박태현

오민수

이광환

홍원

민희경

김관희

주다경

마지환

류현열

김미래

김유라

박윤성

박정원

장혜현

박성호

김소희

신동해

김승준

최희정

지승욱

김재훈

이철주

정성태

김진한

정대균

우주랑

양준혁

이원섭

By studying cellular function switches at the proteomic level, it is possible to develop technologies applicable to the treatment and diagnosis of diseases. Key research areas include structural and functional analysis of disease-related proteins, high-efficiency development of drug discovery target proteins, and biomarker development.

세포기능스위치를 단백체 수준으로 연구하면 질병의 치료와 진단에 응용 가능한 기술을 개발하는 것이 가능하다. 주요 연구분야로 질병관련 단백질의 구조기능 분석, 신약 개발 표적단백질의 고효율 개발, 바이오마커 개발 등을 수행하고 있다

A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex

Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1

Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes

BAFF-neutralizing interaction of belimumab related to its therapeutic efficacy for treating systemic lupus erythematosus

Structural and biochemical analysis of atypically low dephosphorylating activity of human dual-specificity phosphatase 28

Two intermediate states of the conformational switch in dual specificity phosphatase 13a

Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy

BetaCavityWeb: a webserver for molecular voids and channels

The family-wide structure and function of human dual-specificity protein phosphatases

Broadly neutralizing anti-hepatitis B virus antibody reveals a complementarity determining region H3 lid-opening mechanism

Redox regulation of OxyR requires specific disulfide bond formation involving a rapid kinetic reaction path

Structural basis of the redox switch in the OxyR transcription factor

Crystal structure of proteolytic fragments of the redox-sensitive Hsp33 with constitutive chaperone activity

Crystal structure of a novel human peroxidase enzyme at 2.0 A resolution

Crystal structure of an HIV-binding recombinant fragment of human CD4

Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals

Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research

Purification, crystallization and X-ray crystallographic analysis of RPTPH

Structural mechanism of inhibitor-resistance by ERK2 mutations

Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development

Crystal structure of the mouse endonuclease G

MGOS: A library for molecular geometry and its operating system

A novel allosteric inhibitor of protein tyrosine phosphatase sigma

Synthesis and biological evaluation of acylthiourea against DUSP1 inhibition

Virtual screening and biochemical evaluation to identify the allosteric inhibitors of dual specificity phosphatase 1

Crystal structure of the complex of DUSP15 and its inhibitor reveals novel inhibitor binding interactions

Crystallization and preliminary diffraction analysis of dual specificity phosphatase 13a

Crystal structure of an activity-enhancing mutant of DUSP19

Specific binding and catalytic activation of the MAPK-MKP complex

Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab

Crystallization and preliminary diffraction analysis of DUSP28 through identification of a pseudo-thrombin cleavage site

Identification of novel protein tyrosine phosphatase sigma inhibitors promoting neurite extension

BetaSCPWeb: side-chain prediction for protein structures using Voronoi diagrams and geometry prioritization

Structural mobility of the active site in classical protein tyrosine phosphatases and dual specificity phosphatases

Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation

Structural analysis of activity-modulating mutations of DUSP19

Enhanced humanization and affinity maturation of neutralizing anti-hepatitis B virus preS1 antibody based on antigen-antibody complex structure

Targeting allosteric sites for protein tyrosine phosphatase inhibition

Discovery of Novel DUSP4 Inhibitors through the Virtual Screening with Docking Simulations

Discovery of novel DUSP16 phosphatase inhibitors through virtual screening with homology modeled protein structure

Crystallization and preliminary X-ray crystallographic analysis of the PH-GRAM domain of human MTMR4

Expression, purification, crystallization and preliminary crystallographic analysis of human myotubularin-related protein 3

BetaVoid: molecular voids via beta-complexes and Voronoi diagrams

Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates

Dual-mode enhancement of metallothionein protein with cell transduction and retention peptide fusion

Structure of the catalytic domain of protein tyrosine phosphatase sigma in the sulfenic acid form

201Tl heart-liver radioactivity uptake ratio and prediction of decompensation in patients with cirrhosis

Identification of potent VHZ phosphatase inhibitors with structure-based virtual screening

Protein Tyrosine Phosphatase σ in Proteoglycan-Mediated Neural Regeneration Regulation

Homology modeling and virtual screening approaches to identify potent inhibitors of slingshot phosphatase 1

Structure and catalytic mechanism of human protein tyrosine phosphatome

Structure-based de novo design of Eya2 phosphatase inhibitors

Virtual Screening and Biochemical Evaluation of Mitogen-activated Protein Kinase Phosphatase 4 Inhibitors

Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening

Structure and design of broadly-neutralizing antibodies against HIV

Homophilic interaction of the L1 family of cell adhesion molecules

Structural mechanism of disulphide bond-mediated redox switches

Emodin inhibits migration and invasion of DLD-1 (PRL-3) cells via inhibition of PRL-3 phosphatase activity

Structure-based virtual screening approach to the discovery of novel PTPMT1 phosphatase inhibitors

Crystal structure of a novel mitogen-activated protein kinase phosphatase, SKRP1

Enhanced chondrogenic marker expression of human mesenchymal stem cells by interaction with both TGF-β3 and hyaluronic acid

Inhibition of Invasion and Capillary-like Tube Formation by Retrohydroxamate-based MMP Inhibitors

Discovery of Novel Inhibitors of Dual-Specificity Phosphatase Pyst2 with Structure-Based Virtual Screening

Identification of novel inhibitors of mitogen-activated protein kinase phosphatase-1 with structure-based virtual screening

Structural mechanism of the antigen recognition by the L1 cell adhesion molecule antibody A10-A3

Crystal Structure of Constitutively Monomeric E. coli Hsp33 Mutant with Chaperone Activity

Exploring binding sites other than the catalytic core in the crystal structure of the catalytic domain of MKP-4

Identification of two novel VHR phosphatase inhibitors with structure-based virtual screening

Identification of tyrosine-titrated proteins in HT22 hippocampal cells during glutamate-induced oxidative stress

Proteomic analysis of oxidative stress-induced neuronal cell death by using two-dimensional fluorescence difference gel electrophoresis

Vacuolar (H(+))-ATPases in C. elegans: What can we learn about giant H(+) pumps from tiny worms?

Use of dimedone-based chemical probes for sulfenic acid detection evaluation of conditions affecting probe incorporation into redox-sensitive proteins

Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase and a transcription factor

Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn

Broadly neutralizing anti-HBV antibody binds to non-epitope regions of preS1

Structure-based de novo design and biochemical evaluation of novel Cdc25 phosphatase inhibitors

Crystal structure of the catalytic domain of human MKP-2 reveals a 24-mer assembly

Purification, crystallization and data collection of the apoptotic nuclease endonuclease G

Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent

NSC-87877, inhibitor of SHP-1/2 PTPs, inhibits dual-specificity phosphatase 26 (DUSP26)

The diversity of lysine-acetylated proteins in Escherichia coli

Identification of novel inhibitors of extracellular signal-regulated kinase 2 based on the structure-based virtual screening

Identification of proteins binding to decursinol by chemical proteomics

Seong Eon Ryu

Director, Cellular Switch Protein Structure Research Center

Director, Systemic Proteomics Research Center

Clinical Research Advisory Committee Member

Organizing Committee Member/Chair, Academic Conference

Chair, Division of Chemical and Biological Engineering

Professor, Department of Bioengineering, College of Engineering, Hanyang University

Hanyang Univesity Protein Structure and Design Lab

교수님 소개

류성언

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex

Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1

Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

류성언

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

A Dynamic Substrate Pool Revealed by cryo-EM of a Lipid-Preserved Respiratory Supercomplex

Identification of a novel inhibitor of liver cancer cell invasion and proliferation through regulation of Akt and Twist1

Phospholipid transfer function of PTPIP51 at mitochondria-associated ER membranes

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집