Ki-Hong Nam

Sang Ah Yi

Gunhoo Park

Soyoung Han

Jiye Jang

Chaeyoung Lim

Seungwon Yeon

The JPSC Lab focuses on Clinical Pharmacoimmunology, research on establishing autoimmune disease model systems, generation of disease-specific induced pluripotent stem cells, development of various disease modeling technologies using patient-derived induced pluripotent stem cells, establishment of drug screening systems using induced pluripotent stem cells, research on developing cell therapy-based biopharmaceuticals, and establishment of structure-based genome integrated control systems.

JPSC Lab은 임상약품면역학, 자가면역질환 모델 시스템 확립 연구, 질환 특이적인 역분화 줄기세포 생성, 환자의 역분화 줄기세포를 이용한 다양한 질환 modeling 기술 개발, 역분화 줄기세포를 이용한 drug screening system 구축, 세포치료제 기반 바이오 의약품 개발 연구, 구조 기반 유전체 통합 조절 시스템 구축에 중점을 둡니다.

Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor

S6K1 controls adiponectin expression by inducing a transcriptional switch: BMAL1-to-EZH2

Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy

SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation

Regulation of p53 Activity by Protein L-isoaspartyl Methyltransferase

Modeling doxorubicin-induced-cardiotoxicity through breast cancer patient specific iPSC-derived heart organoid

Structure-guided Engineering of Thermodynamically Enhanced SaCas9 for Improved Gene Suppression

PIV-MyoMonitor: an accessible particle image velocimetry-based software tool for advanced contractility assessment of cardiac organoids

Peptide-Drug Conjugate with Statistically Designed Transcellular Peptide for Psoriasis-Like Inflammation

Mussel-Inspired Recombinant Adhesive Protein-Based Functionalization for Consistent and Effective Antimicrobial Treatment in Chronic Inflammatory Skin Diseases

Application of RapidHIT™ ID for cell authentication by fast and convenient STR profiling

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator

Effect of Secondary Structures on the Adsorption of Peptides onto Hydrophobic Solid Surfaces Revealed by SALDI-TOF and MD Simulations

Nuclear S6K1 regulates cAMP-responsive element-dependent gene transcription through activation of mTOR signal pathway

Transcriptomics-Based Repositioning of Natural Compound, Eudesmin, as a PRC2 Modulator

Human WRN is an intrinsic inhibitor of progerin, abnormal splicing product of lamin A

Small-molecule probe reveals a kinase cascade that links stress signaling to TCF/LEF and Wnt responsiveness

Anti-Adipogenic Polyacetylene Glycosides from the Florets of Safflower (Carthamus tinctorius)

Rosmarinic Acid Methyl Ester Regulates Ovarian Cancer Cell Migration and Reverses Cisplatin Resistance by Inhibiting the Expression of Forkhead Box M1

Infection of brain organoids and 2D cortical neurons with SARS-CoV-2 pseudovirus

In vitro modeling for inherited neurological diseases using induced pluripotent stem cells: from 2D to organoid

Discovery of Dihydrophaseic Acid Glucosides from the Florets of Carthamus tinctorius

HPV-mediated nuclear export of HP1γ drives cervical tumorigenesis by downregulation of p53

Ginsenoside Rg3 Induces Browning of 3T3-L1 Adipocytes by Activating AMPK Signaling

(±)-Kituramides A and B, pairs of enantiomeric dopamine dimers from the two-spotted cricket Gryllus bimaculatus

Vulpinic Acid Controls Stem Cell Fate toward Osteogenesis and Adipogenesis

Anti-adipogenic Effect of β-Carboline Alkaloids from Garlic (Allium sativum)

Pantheric Acids A-C from a Poisonous Mushroom, Amanita pantherina, Promote Lipid Accumulation in Adipocytes

Identification of a novel S6K1 inhibitor, rosmarinic acid methyl ester, for treating cisplatin-resistant cervical cancer

Modelling diastolic dysfunction in induced pluripotent stem cell-derived cardiomyocytes from hypertrophic cardiomyopathy patients

Human-Induced Pluripotent Stem Cell Model of Trastuzumab-Induced Cardiac Dysfunction in Patients With Breast Cancer

Defining human cardiac transcription factor hierarchies using integrated single-cell heterogeneity analysis

Large-Scale Single-Cell RNA-Seq Reveals Molecular Signatures of Heterogeneous Populations of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells

Cell type-specific chromatin signatures underline regulatory DNA elements in human induced pluripotent stem cells and somatic cells

Transcriptomic and Epigenomic Differences in Human Induced Pluripotent Stem Cells Generated from Six Reprogramming Methods

Ginsenoside Rg1 from Panax ginseng Enhances Myoblast Differentiation and Myotube Growth

Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness

Patient-Specific iPSC-Derived Endothelial Cells Uncover Pathways that Protect against Pulmonary Hypertension in BMPR2 Mutation Carriers

A Comprehensive TALEN-Based Knockout Library for Generating Human Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases

S6K1 Phosphorylation of H2B Mediates EZH2 Trimethylation of H3: A Determinant of Early Adipogenesis

Generation of functional cardiomyocytes from the synoviocytes of patients with rheumatoid arthritis via induced pluripotent stem cells

Transcriptional Regulation of Cancer Stem Cell Marker CD133 by Tumor Suppresser p53

Epigenetic Regulation of Phosphodiesterases 2A and 3A Underlies Compromised β-adrenergic Signaling in an iPSC Model of Dilated Cardiomyopathy

Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency

Pravastatin Reverses Dysfunction of Pre-Diabetic Induced Pluripotent Stem Cell Derived Endothelial Cells via a Nitric Oxide-Dependent Mechanism

Epigenetic Activation of the Foxa2 Gene Is Required for Maintaining the Potential of Neural Precursor Cells to Differentiate into Dopaminergic Neurons after Expansion

Molecular mechanism underlying increased ischemic damage in the ALDH22 genetic polymorphism using a human iPSC model system

Recent technological updates and clinical applications of induced pluripotent stem cells

Generation of disease-specific induced pluripotent stem cells from patients with rheumatoid arthritis and osteoarthritis

Requirement of Protein L-Isoaspartyl Methyltransferase for Transcriptional Activation of Trefoil Factor 1 (TFF1) Gene by Estrogen Receptor Alpha

Destabilization of TNF-α mRNA by Rapamycin

A Fermented Ginseng Extract, BST204, Inhibits Proliferation and Motility of Human Colon Cancer Cells

Depletion of Embryonic Stem Cell-Like Signature by HDACI in NCCIT Cells: Involvement of Nanog Down-Regulation

Rapamycin down-regulates inducible nitric oxide synthase by inducing proteasomal degradation

Reversine Increases the Plasticity of Lineage-Committed Cells Toward Neuroectodermal Lineage

Histone deacetylase inhibitor apicidin downregulates DNA methyltransferase 1 expression and induces repressive histone modifications via recruitment of corepressor complex to promoter region in human cervix cancer cells

PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells

Suppression of the NF-κB Signaling Pathway by Ergolide, Sesquiterpene Lactone, in HeLa cells

Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites

JPSC Lab

교수님 소개

이 재 철

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor

Modeling doxorubicin-induced-cardiotoxicity through breast cancer patient specific iPSC-derived heart organoid

Structure-guided Engineering of Thermodynamically Enhanced SaCas9 for Improved Gene Suppression

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

이 재 철

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Precise editing of pathogenic nucleotide repeat expansions in iPSCs using paired prime editor

Modeling doxorubicin-induced-cardiotoxicity through breast cancer patient specific iPSC-derived heart organoid

Structure-guided Engineering of Thermodynamically Enhanced SaCas9 for Improved Gene Suppression

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집