Uncovering the Physical Principles of Life to Drive Biological Innovation. Welcome to the PoLS research group in the Department of Physics at Yonsei University! We aim to uncover the fundamental physical principles governing living systems and leverage these insights to engineer innovative tools for solving complex challenges in biology. Our current research focuses on the collective behaviors of biomolecules driven by weak and transient interactions- specifically those forming biomolecular condensates. By integrating high-resolution live-cell imaging, multi-omics approaches, and synthetic biology, we investigate how these condensates regulate cellular functions. Our multidisciplinary approach seeks to establish new conceptual frameworks for understanding and addressing biological mechanisms underlying cancer and neurodegenerative disorders.

연세대학교 생체물리 연구실(PoLS)은 생물 시스템의 근본적인 물리적 원리를 탐구합니다. 우리는 분자 상호작용부터 세포 조직 및 유기체의 집단 행동에 이르기까지 다양한 규모에서 연구를 수행합니다. 살아있는 물질이 어떻게 스스로 조직화되고, 정보를 처리하며, 환경에 적응하는지 밝히기 위해 이론적 모델링, 전산 시뮬레이션 및 실험 기술을 결합하여 사용합니다. 우리의 목표는 생명체의 복잡한 현상에 대한 더 깊은 이해에 기여하고 생명공학 및 의학과 같은 분야에서 새로운 접근 방식을 고취하는 것입니다.

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

Direct observation of a condensate effect on super-enhancer controlled gene bursting

Oxygen deficiency defects in amorphous Al2O3

A dual role for H2A.Z.1 in modulating the dynamics of RNA polymerase II initiation and elongation

Electronic structure of Pd thin films on Re(0001) studied by high-resolution core-level and valence-band photoemission

A CRISPR/Cas9 platform for MS2-labelling of single mRNA in live stem cells

Light-induced targeting enables proteomics on endogenous condensates

The Chemical Reaction of Diethyl Carbonate with Lithium Intercalated Graphite Studied by X-Ray Photoelectron Spectroscopy

Selective Detection of Single-Stranded DNA Molecules Using a Glass Nanocapillary Functionalized with DNA

Charge loss behavior of a metal-alumina-nitride-oxide-silicon-type flash memory cell with different levels of charge injection

A photoemission study of Pd ultrathin films on Pt (111)

Clinical Experience with Use of Remdesivir in the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2: a Case Series

Measurement-Based Electric Arc Furnace Model Using Ellipse Formula

DC Power Control Strategy of MMC for Commutation Failure Prevention in Hybrid Multi-Terminal HVDC System

Equivalent load estimation method for determining railway power requirements under extended feeding conditions using a simplex algorithm

A Framework to Analyze the Stochastic Harmonics and Resonance of Wind Energy Grid Interconnection

Operation Method of Energy Storage System Replacing Governor for Frequency Regulation of Synchronous Generator without Reserve

Reserve replacement from governor to energy storage system on conventional generator for operating-cost reduction

A dual role for H2A.Z.1 in modulating the dynamics of RNA Polymerase II initiation and elongation

Active Brownian particles in confinement

Self-organization of cytoskeletal filaments

Social support and posttraumatic stress disorder: A meta-analysis of longitudinal studies

Antibiotic Resistance As a Stress Response: Complete Sequencing of a Large Number of Chromosomal Loci in <i>Staphylococcus aureus</i> Strain COL That Impact on the Expression of Resistance to Methicillin

Mastery or mystery? Therapeutic writing: A review of the literature

Childhood trauma in obsessive compulsive disorder: The roles of alexithymia and attachment

Investigating Burnout and Psychological Well‐Being of Staff Working with People with Intellectual Disabilities and Challenging Behaviour: The Role of Personality

Maladaptive behaviour in Prader‐Willi syndrome in adult life

A Multiple-Indicator Multiple-Cause Model for Posttraumatic Stress Reactions: Personality, Coping, and Maladjustment

The path to care in autism: Is it better now?

Nutrition education in European medical schools: results of an international survey

Coping with post‐traumatic stress symptoms following relationship dissolution

Posttraumatic Stress Among Syrian Refugees: Trauma Exposure Characteristics, Trauma Centrality, and Emotional Suppression

Posttraumatic stress disorder in older people after a fall

The impact of trauma exposure characteristics on post-traumatic stress disorder and psychiatric co-morbidity among Syrian refugees

Maladaptive behaviour in Prader-Willi syndrome in adult life

Editorial: Psychological Distress Among University Students

‘Shame on you’ – the psychosocial impact of genital warts

Self‐esteem, personality and post traumatic stress symptoms following the dissolution of a dating relationship

Classification of psychotic symptoms in dementia sufferers

The relationship between trauma centrality, self-efficacy, posttraumatic stress and psychiatric co-morbidity among Syrian refugees: Is gender a moderator?

Posttraumatic stress disorder and general health problems following myocardial infarction (Post‐MI PTSD) among older patients: the role of personality

Choongman Lee

Principal Investigator

Physics of Living Systems Lab

교수님 소개

이충만

연구실 소개

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Direct observation of a condensate effect on super-enhancer controlled gene bursting

Direct observation of a condensate effect on super-enhancer controlled gene bursting

Light-induced targeting enables proteomics on endogenous condensates

연구실 보유 특허

대학별 입시끈

우리 연구실 모집

교수님 소개

이충만

연구실 키워드

알럼나이가 간 회사

연구실 지원 방법

대우 조건

연도별 논문 인용수

저널 & 학회 논문 출판 수

연구실 논문 목록

Direct observation of a condensate effect on super-enhancer controlled gene bursting

Direct observation of a condensate effect on super-enhancer controlled gene bursting

Light-induced targeting enables proteomics on endogenous condensates

연구실 보유 특허

최근 3년간 연구실적 높은 연구실

대학별 입시끈

우리 연구실 모집